In this study, using a mouse model, we determined whether vitamin D deficiency in utero and during early life modulated the severity of asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

With more than one in four Australian children overweight or obese, and the significant risks this poses for health problems like asthma, depression,... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

Genome-wide association studies (GWASs) have been successful at identifying single-nucleotide polymorphisms (SNPs) highly associated with common traits... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• August 2012

Ankylosing spondylitis is a common form of inflammatory arthritis predominantly affecting the spine and pelvis that occurs in approximately 5 out of 1,000 adult ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• August 2011

Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

Applied Spatial Statistics used in conjunction with geographic information systems (GIS) provide an efficient tool for the surveillance of diseases ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• February 2010

Secondary prophylaxis to prevent rheumatic heart disease (RHD) progression, in the form of four-weekly intramuscular benzathine benzylpenicillin G (BPG) injections, has remained unchanged since 1955. Qualitative investigations into patient preference have highlighted the need for long-acting penicillins to be delivered less frequently, ideally with reduced pain. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• April 2023

Genevieve Sarra Jenefer Syn Jamieson Blackwell GS SE JM BSc (Hons), PhD BSc (Hons) MSc PhD BSc with First Class Honours, PhD, DSc, FMedSci, FAA Research Officer Senior Research Fellow Head, Genetics & Health (08) 6319 1549 Genevieve.syn@ ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Emma Glenn Martyn Adams Pearson Symons EA G MS BExSc, MPH BA (Education) PhD Candidate B.A. (Hons) PhD. Acting Research Officer -Playce, Research Assistant & PhD student Director of First Nations Strategy and Leadership Honorary Research Associate ...

• 1. Telethon Kids Institute
• Projects

Gail Prue Shelley Alvares Hart Gorman GA PH S PhD BSc (Hons) MSc PhD BSc (Hons) PhD Senior Research Fellow Head, Inflammation Honorary Research Associate 08 6319 1698 gail.alvares@telethonkids.org.au prue.hart@telethonkids.org.au shelley.gorman@ ...

• 1. Telethon Kids Institute
• Projects

Despite education about the risks of excessive sun exposure, teenagers in Australia are sun-seeking, with sunburn common in summer. Conversely, some regular (time-limited) exposure to sunlight (that avoids sunburn) is necessary for vitamin D and healthy bones and other molecules important for immune and metabolic health. New interventions are thus required to better support teenagers to make healthy and balanced decisions about their sun behaviors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022