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        565-576 of 678 results for 'CANCER'

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        Developmental vulnerabilities in children of chronically ill parents: A population-based linked data study

        Maternal chronic illness is associated with an increased risk of poor developmental outcomes for children, particularly daughters ...

        Research

        Early childhood development of boys with genital anomalies

        We found no increased risk of poor development among boys with hypospadias or undescended testis ...

        Research

        DeepCAGE transcriptomics identify HOXD10 as a transcription factor regulating lymphatic endothelial responses to VEGF-C

        The role of HOXD10 in the regulation of VEGFR-3 signaling in lymphatic endothelial cells, and in the control of lymphangiogenesis and permeability ...

        Research

        Ultraviolet radiation exposure and serum vitamin D levels in young children

        This paper examined the link between UV exposure and vitamin D production in young children to determine how long it takes for sun exposure to affect serum... ...

        Research

        Novel oncogenic PDGFRA mutations in pediatric high-grade gliomas

        The outcome for children with high-grade gliomas (HGG) remains dismal, with a 2-year survival rate of only 10% to 30%. ...

        Research

        Aminoglycoside use in paediatric febrile neutropenia - Outcomes from a nationwide prospective cohort study

        Aminoglycosides are commonly prescribed to children with febrile neutropenia (FN) but their impact on clinical outcomes is uncertain and extent of guideline compliance is unknown. We aimed to review aminoglycoside prescription and additional antibiotic prescribing, guideline compliance and outcomes for children with FN. ...

        Research

        Maternal consumption of coffee and tea during pregnancy and risk of childhood ALL: a pooled analysis from the childhood Leukemia International Consortium

        Our findings suggest that high coffee intake during pregnancy may increase risk of childhood acute lymphoblastic leukemia ...

        Research

        Protection against severe infant lower respiratory tract infections by immune training: Mechanistic studies

        Results from recent clinical studies suggest potential efficacy of immune training (IT)-based approaches for protection against severe lower respiratory tract infections in infants, but underlying mechanisms are unclear. ...

        Research

        IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

        High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

        Research

        Assessing the utility of routine viral surveillance performed in children undergoing autologous stem cell transplantation at a single centre

        We assessed the utility of routine viral surveillance for cytomegalovirus, Epstein–Barr virus and human adenovirus in children <16 years, undergoing autologous stem cell transplantation (ASCT) at a single centre over a 10-year period. A total of 85 ASCT were performed in 65 patients. ...

        Research

        Understanding acute burn injury as a chronic disease

        The review will outline evidence of long-term health effects, possible mechanisms linking burn injury to long-term health and current research into burns as a chronic disease ...

        Research

        C1 CAGE detects transcription start sites and enhancer activity at single-cell resolution.

        We introduce C1 CAGE, a method for the detection of transcript 5'-ends with an original sample multiplexing strategy in the C1TM microfluidic system ...

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