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        565-576 of 684 results for 'diabetes'

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        Meta-taxonomic analysis of prokaryotic and eukaryotic gut flora in stool samples from visceral leishmaniasis cases and endemic controls in Bihar State India

        We evaluate a meta-taxonomic approach to determine the composition of prokaryotic and eukaryotic gut microflora using sequencing of 16S RNA and 18S rRNA ...

        Research

        A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1

        To identify new susceptibility loci for psoriasis, we undertook a genome-wide association study of 594,224 SNPs in 2,622 individuals with psoriasis... ...

        Research

        Association of a NOD2 gene polymorphism and T-helper 17 cells with presumed ocular toxoplasmosis

        We assessed 30 sibships and 89 parent/case trios of presumed ocular toxoplasmosis (POT) to evaluate associations with polymorphisms in the NOD2 gene. ...

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        "Hurts less, lasts longer"; a qualitative study on experiences of young people receiving high-dose subcutaneous injections of benzathine penicillin G to prevent rheumatic heart disease in New Zealand

        Four-weekly intramuscular benzathine penicillin G injections to prevent acute rheumatic fever progression have remained unchanged since 1955. A Phase-I trial in healthy volunteers demonstrated the safety and tolerability of high-dose subcutaneous infusions of BPG which resulted in a much longer effective penicillin exposure, and fewer injections. Here we describe the experiences of young people living with ARF participating in a Phase-II trial of SubCutaneous Injections of BPG. ...

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        Profiling the Longitudinal Development of Babbling in Infants with Cerebral Palsy: Validation of the Infant Monitor of Vocal Production (IMP) Using the Stark Assessment of Early Vocal Development-Revised (SAEVD-R)

        We compared early vocal development in children "at risk" for cerebral palsy (CP) with typically developing (TD) infants aged 6 to 15 months using the SAEVD-R, investigating potential pre-linguistic markers of communication impairment. Additionally, we sought to examine the agreement between the SAEVD-R and IMP, which uses parent report, in identifying departure from typical vocal development in at-risk infants. ...

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        Toward homeostasis: Regulatory dendritic cells from the bone marrow of mice with inflammation

        Inflammatory mediators from peripheral tissues may control dendritic cell (DC) development in the bone marrow. ...

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        Cytokine responses to novel antigens in a peri-urban population in Brazil exposed to Leishmania infantum chagasi

        Visceral leishmaniasis (VL) is fatal if untreated, and there are no vaccines for this disease ...

        Research

        Metabolic dysfunction induced by a high-fat diet modulates hematopoietic stem and myeloid progenitor cells in brown adipose tissue of mice

        Brown adipose tissue (BAT) may be an important metabolic regulator of whole-body glucose. While important roles have been ascribed to macrophages in regulating metabolic functions in BAT, little is known of the roles of other immune cells subsets, particularly dendritic cells (DCs). Eating a high-fat diet may compromise the development of hematopoietic stem and progenitor cells (HSPCs)-which give rise to DCs-in bone marrow, with less known of its effects in BAT. We have previously demonstrated that ongoing exposure to low-dose ultraviolet radiation (UVR) significantly reduced the 'whitening' effect of eating a high-fat diet upon interscapular (i) BAT of mice. ...

        Research

        Sub-erythemal ultraviolet radiation reduces metabolic dysfunction in already overweight mice

        Exposure to sunlight may limit cardiometabolic risk. ...

        Research

        A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

        These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

        Research

        Can skin exposure to sunlight prevent liver inflammation?

        Here we discuss how skin exposure to sunlight may suppress liver inflammation and the severity of NAFLD. ...

        Research

        25-hydroxyvitamin D status of pregnant women is associated with the use of antenatal vitamin supplements and ambient ultraviolet radiation

        Vitamin D deficiency in a predominantly white Caucasian cohort of pregnant women is less prevalent than has been reported in other studies ...

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