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        Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease

        Cystic fibrosis (CF) airway disease is characterized by chronic inflammation, featuring neutrophil influx to the lumen. Airway macrophages (AMs) can promote both inflammation and resolution, and are thus critical to maintaining and restoring homeostasis. CF AM functions, specifically scavenging activity and resolution of inflammation, have been shown to be impaired, yet underlying processes remain unknown. ...

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        Macrophage infectivity potentiator protein, a peptidyl prolyl cis-trans isomerase, essential for Coxiella burnetii growth and pathogenesis

        Coxiella burnetii is a Gram-negative intracellular pathogen that causes the debilitating disease Q fever, which affects both animals and humans. The only available human vaccine, Q-Vax, is effective but has a high risk of severe adverse reactions, limiting its use as a countermeasure to contain outbreaks. Therefore, it is essential to identify new drug targets to treat this infection. ...

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        Composition and diversity of gut microbiota

        The gastrointestinal tract has one of the most diverse and complex microbial communities in nature which is shaped by both external and internal factors throughout a human's lifespan. The gut microbiota and the host have coevolved and coexisted to create a mutualistic relationship as the bacterial community has many functions in the body. ...

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        Asthma

        One in eight children have asthma, a chronic disease of the airways in the lungs. It results in shortness of breath, chest tightness, wheezing and coughing. ...

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        Rhinovirus Infection Is Associated With Airway Epithelial Cell Necrosis and Inflammation via Interleukin-1 in Young Children With Cystic Fibrosis

        This study found rhinovirus infection drives necrotic cell death in cystic fibrosis airway epithelial cells ...

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        A Novel Missense Mutation Affecting the N-terminal Domain of SAP Protein in X-linked Lymphoproliferative Disease

        We have revealed a novel SH2D1A gene mutation in a patient with XLP resulting in fulminant refractory EBV-driven HLH, which is a recognized severe complication ...

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        The impact of pre-pregnancy body mass index and gestational weight gain on placental abruption risk: a systematic review and meta-analysis

        Mothers that are underweight prior to or in early pregnancy are at a moderately increased risk of placental abruption ...

        Research

        Standardization of Spirometry 2019 Update. An Official American Thoracic Society and European Respiratory Society Technical Statement

        Standards and consensus recommendations are presented for manufacturers, clinicians, operators, and researchers ...

        Research

        Inflammatory bowel diseases: interrelationships between dietary vitamin D, exposure to UV radiation and the fecal microbiome

        This review explores the interaction of vitamin D, and ultraviolet radiation, with the intestinal innate and adaptive immune systems ...

        Research

        Family history of cancer and the risk of childhood brain tumors: a pooled analysis of the ESCALE and ESTELLE studies (SFCE)

        Our findings support the hypothesis of a familial susceptibility of childhood brain tumors, not due to being a known neurofibromatosis carrier ...

        Research

        Use of remote monitoring with continuous glucose monitoring in young children with Type 1 diabetes: the parents’ perspective

        Parents of primary school children reported that using remote monitoring and continuous glucose monitoring was a mostly beneficial experience ...

        Research

        Propofol use in children with allergies to egg, peanut, soybean or other legumes

        We conclude that genuine serious allergic reaction to propofol is rare and is not reliably predicted by a history of food allergy ...

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