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        49-60 of 115 results for 'Professor Stephen Stick'

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        The next generation of impact in cystic fibrosis

        Lung damage in children with CF occurs much earlier than previously thought, and proving this is related to the decline that occurs later will create new paradigms for prevention and treatment. ...

        Research

        Novel end points for clinical trials in young children with cystic fibrosis

        Cystic fibrosis (CF) lung disease commences early in the disease progression and is the most common cause of mortality. ...

        Research

        Interferon β-1a ring prophylaxis to reduce household transmission of SARS-CoV-2: a cluster randomised clinical trial

        Accumulating evidence indicates that an early, robust type 1 interferon (IFN) response to SARS-CoV-2 is important in determining COVID-19 outcomes, with an inadequate IFN response associated with disease severity. Our objective was to examine the prophylactic potential of IFN administration to limit viral transmission. ...

        Research

        Lung inflammation and simulated airway resistance in infants with cystic fibrosis

        Cystic fibrosis (CF) is characterized by small airway disease; but central airways may also be affected. We hypothesized that airway resistance estimated from computational fluid dynamic (CFD) methodology in infants with CF was higher than controls and that early airway inflammation in infants with CF is associated with airway resistance. ...

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        Respiratory function and symptoms in young preterm children in the contemporary era

        Preterm children have worse lung function than healthy controls ...

        Research

        SYNERGY CF: Getting the best start to life - preventing early cystic fibrosis lung disease by solving the host-inflammation infection conundrum

        Anthony Stephen Yuliya Kicic Stick Karpievitch A SM YK BSc (Hons) PhD MB BChir PhD MRCP FRACP PhD, MS, BS Rothwell Family Fellow; Head, Airway Epithelial Research Head, P4 Respiratory Health for Kids Ai and Data Analytics Lead, Respiratory Research ...

        Research

        Characterization of maximal respiratory pressures in healthy children

        Measurements of maximal voluntary inspiratory (Pi max) and expiratory (Pe max) pressures are used in the management of respiratory muscle disease... ...

        Research

        Infection, inflammation,and lung function decline in infants with cystic fibrosis

        Better understanding of evolution of lung function in infants with cystic fibrosis... ...

        Research

        The safety and feasibility of the inhaled mannitol challenge test in young children

        Mannitol challenge tests are used clinically to diagnose asthma and, in particular, exercise-induced broncoconstriction (EIB) in adults and children above 6... ...

        Research

        Expiratory flow limitation and breathing strategies in overweight adolescents during submaximal exercise

        Young people who are overweight/obese are more likely to display expFL during submaximal exercise compared with children of healthy weight. ...

        Research

        Elastase Exocytosis by Airway Neutrophils Associates with Early Lung Damage in Cystic Fibrosis Children

        Protease elastase exocytosis by airway neutrophils occurs in all cystic fibrosis children, and its cellular measure correlates with early lung damage ...

        Research

        Matrix metalloproteinase activation by free neutrophil elastase contributes to bronchiectasis progression in early cystic fibrosis

        The aim of this study was to assess if MMP activation positively correlates with neutrophil elastase activity, disease severity and bronchiectasis in young... ...

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