B lymphopoiesis is characterized by progressive loss of multipotent potential in hematopoi-etic stem cells, followed by commitment to differentiate into B cells, which mediate the humoral response of the adaptive immune system. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Early intensification with postinduction myeloid-type chemotherapy courses did not significantly improve outcome for infant acute lymphoblastic leukemia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

We found two known risk factors in a large cohort of children treated for ALL and identified other factors associated with venous thromboembolism ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

We undertook a retrospective review of children diagnosed with acute lymphoblastic leukemia (ALL) and treated with modern COG protocols to determine... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• June 2015

The epidemiological, prognostic, and therapeutic features of child and adolescent meningioma are poorly defined... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• November 2011

Invasive fungal infections are more common in children with high-risk acute lymphoblastic leukaemia and in relapsed disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stromal and immune cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Recent research showed that precision medicine can identify new treatment strategies for patients with childhood cancers. However, it is unclear which patients will benefit most from precision-guided treatment. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• June 2024

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Invasive fungal disease (IFD) is a common and important complication in children with acute myeloid leukaemia (AML). We describe the epidemiology of IFD in a large multicentre cohort of children with AML. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

There is a high incidence of vaccine-preventable morbidity post-allogeneic haematopoietic stem cell transplantation in West Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Our case demonstrates that AML therapy, without HSCT, can be sufficient to treat this rare disease in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• March 2013