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        Clinical experience with SUBA-itraconazole at a tertiary paediatric hospital

        Itraconazole remains a first-line antifungal agent for certain fungal infections in children, including allergic bronchopulmonary aspergillosis (ABPA) and sporotrichosis, but poor attainment of therapeutic drug levels is frequently observed with available oral formulations. A formulation of 'SUper BioAvailability itraconazole' (SUBA-itraconazole; Lozanoc®) has been developed, with adult studies demonstrating rapid and reliable attainment of therapeutic levels, yet paediatric data are lacking. ...

        Research

        Has COVID19 derailed Bhutan's national malaria elimination goal? A commentary

        The COVID-19 pandemic has resulted in massive global disruptions with considerable impact on the delivery of health services and national health programmes. Since the detection of the first COVID-19 case on 5th March 2020, the Royal Government of Bhutan implemented a number of containment measures including border closure and national lockdowns. Against the backdrop of this global COVID-19 pandemic response, there was a sudden surge of locally-transmitted malaria cases between June to August 2020. ...

        Research

        COVID-19, children and schools: overlooked and at risk

        We have closely followed the international literature about severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) transmission dynamics in children (aged 0–18 years).2 Evidence‐informed discussion about school attendance in the context of COVID‐19 is a high priority and this complex subject requires weighted expert review of the literature to accurately inform policy. As paediatricians and infectious diseases specialists, we wish to highlight important considerations when interpreting the available data. ...

        Research

        Global economic costs due to vivax malaria and the potential impact of its radical cure: A modelling study

        An estimated 14 million cases of Plasmodium vivax malaria were reported from Asia, Central and South America, and the Horn of Africa. The clinical burden of vivax malaria is largely driven by its ability to form dormant liver stages (hypnozoites) that can reactivate to cause recurrent episodes of malaria. Elimination of both the blood and liver stages of the parasites ("radical cure") is required to achieve a sustained clinical response and prevent ongoing transmission of the parasite. ...

        Research

        Spatial prediction of malaria prevalence in Papua New Guinea: a comparison of Bayesian decision network and multivariate regression modelling approaches for improved accuracy in prevalence prediction

        Considerable progress towards controlling malaria has been made in Papua New Guinea through the national malaria control programme's free distribution of long-lasting insecticidal nets, improved diagnosis with rapid diagnostic tests and improved access to artemisinin combination therapy. Predictive prevalence maps can help to inform targeted interventions and monitor changes in malaria epidemiology over time as control efforts continue. ...

        Research

        Childhood vaccination coverage in Australia: an equity perspective

        This study describes trends in social inequities in first dose measles-mumps-rubella (MMR1) vaccination coverage in Western Australia (WA) and New South Wales (NSW). ...

        Research

        Infectious diseases clinician's variation in the management of pediatric Staphylococcus aureus bacteraemia and equipoise for clinical trials

        Large variation in antibiotic prescribing amongst clinicians is demonstrated and increased, corresponding with escalating case complexity and persisting MRSA bacteraemia ...

        Research

        Impact of influenza on hospitalization rates in children with a range of chronic lung diseases

        This large population-based study suggests a significant healthcare burden associated with influenza in children with a range of chronic lung diseases ...

        Research

        Postvaccination Febrile Seizure Severity and Outcome

        Vaccine-proximate febrile seizures accounted for a small proportion of all febrile seizures hospital presentations ...

        Research

        Intraseason decline in influenza vaccine effectiveness during the 2016 southern hemisphere influenza season: A test-negative design study and phylogenetic assessment

        Overall, the 2016 influenza vaccine showed good protection against laboratory-confirmed infection among general practice patients ...

        Research

        Risk factors for multidrug-resistant tuberculosis in northwest Ethiopia: A case–control study

        The aim of this study was to describe the characteristics of patients with multidrug-resistant tuberculosis and to investigate risk factors ...

        Research

        Impact of multidrug-resistant tuberculosis and its medications on adverse maternal and perinatal outcomes: Protocol for a systematic review and meta-Analysis

        We aim to determine whether multidrug-resistant tuberculosis and its medications during pregnancy impact maternal and perinatal outcomes ...

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