Asthma and chronic obstructive pulmonary disease (COPD) are common chronic respiratory diseases, and some patients have overlapping disease features, termed asthma-COPD overlap. Patients characterized with ACO have increased disease severity; however, the mechanisms driving this have not been widely studied. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

In the present study, we sought to evaluate the complement activation product C4d as a marker for lupus nephritis in systemic lupus erythematosus (SLE). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• December 2017

This study identified that expsoure to folate has effects on the regulation of DNA methylation during fetal development. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

Nanoparticles are being developed for diverse biomedical applications, but there is concern about potential to promote inflammation, particularly in the lungs. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• February 2012

Asthma is a chronic inflammatory disease of the small and large conducting airway mucosa characterised by Th2 cell immunity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• April 2010

This chapter describes the preparation of respiratory tract tissue from both mice and rats for the isolation of respiratory tract dendritic cells (RTDC). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• January 2010

We have recently published a paper identifying precursor populations in peripheral lung (2017), and have also discovered that these populations can be found in multiple tissues. Currently, dogma focuses on the bone marrow as the source for these ...

• 1. Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program
• Pregnancy and Early Life Immunology

Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Early Environment
• Immunobiology & Immunotherapeutic Program
• Pregnancy and Early Life Immunology

The aim of this review was to map the literature assessing associations between maternal or infant immune or gut microbiome biomarkers and child neurodevelopmental outcomes within the first 5 years of life. We conducted a PRISMA-ScR compliant review of peer-reviewed, English-language journal articles. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Malaria is a deadly disease caused by Plasmodium spp. Several blood phenotypes have been associated with malarial resistance, which suggests a genetic component to immune protection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023