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        Multiple breath washout cannot be used for tidal breath parameter analysis in infants

        There are differences in tidal breathing parameters during multiple breath washout testing with SF6 gas mixture in infants ...

        Research

        Consensus statement for inert gas washout measurement using multiple- and single- breath tests

        Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago. ...

        Research

        Western Australia Paediatric Bronchiectasis Cohort

        Kathryn André Yuliya Alana Ramsey Schultz Karpievitch Harper KR AS YK AH BSc (Hons), PhD MBChB, PhD, FRACP PhD, MS, BS BSc (hons) Co-Head, Children's Lung Health Program Head, Respiratory Health RFA Ai and Data Analytics Lead, Respiratory Research ...

        Research

        Prematurity-associated lung disease: is it asthma?

        Shannon Elizabeth Simpson Smith SS ES BMedSci (hons), PhD PhD, MSc, BSc Co-Head, Children's Lung Health; Senior Research Fellow Program Manager 08 6319 1631 08 6319 1178 Shannon.simpson@telethonkids.org.au elizabeth.smith@telethonkids.org.au Co-Head ...

        Research

        Lung function changes in children exposed to mine fire smoke in infancy

        Chronic, low-intensity air pollution exposure has been consistently associated with reduced lung function throughout childhood. However, there is limited research regarding the implications of acute, high-intensity air pollution exposure. We aimed to determine whether there were any associations between early life exposure to such an episode and lung growth trajectories. ...

        Research

        Early life predictors of obstructive sleep apnoea in young adults: Insights from a longitudinal community cohort (Raine study)

        Obstructive sleep apnea (OSA) increases the risk of perioperative adverse events in children. While polysomnography (PSG) remains the reference standard for OSA diagnosis, oximetry is a valuable screening tool. The traditional practice is the manual analysis of desaturation clusters derived from a tabletop device using the McGill oximetry score. However, automated analysis of wearable oximetry data can be an alternative. This study investigated the accuracy of wrist-worn oximetry with automated analysis as a preoperative OSA screening tool. ...

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        Increasing airway obstruction through life following bronchopulmonary dysplasia: a meta-analysis

        Few studies exist investigating lung function trajectories of those born preterm; however growing evidence suggests some individuals experience increasing airway obstruction throughout life. Here we use the studies identified in a recent systematic review to provide the first meta-analysis investigating the impact of preterm birth on airway obstruction measured by the forced expiratory volume in 1 s (FEV1) to forced vital capacity (FVC) ratio. ...

        Research

        Normal values of respiratory oscillometry in South African children and adolescents

        Noninvasive measurement of respiratory impedance by oscillometry can be used in young children aged from 3 years and those unable to perform forced respiratory manoeuvres. It can discriminate between healthy children and those with respiratory disease. However, its clinical application is limited by the lack of reference data for African paediatric populations. The aim of the present study was to develop reference equations for oscillometry outcomes in South African children and adolescents. ...

        Research

        Host-dependent resistance of Group A Streptococcus to sulfamethoxazole mediated by a horizontally-acquired reduced folate transporter

        Described antimicrobial resistance mechanisms enable bacteria to avoid the direct effects of antibiotics and can be monitored by in vitro susceptibility testing and genetic methods. Here we describe a mechanism of sulfamethoxazole resistance that requires a host metabolite for activity. ...

        Research

        Normative data for multiple breath washout outcomes in school-aged Caucasian children

        The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

        Research

        A brief history of MECP2 duplication syndrome: 20-years of clinical understanding

        MECP2 duplication syndrome (MDS) is a rare, X-linked, neurodevelopmental disorder caused by a duplication of the methyl-CpG-binding protein 2 (MECP2) gene-a gene in which loss-of-function mutations lead to Rett syndrome (RTT). MDS has an estimated live birth prevalence in males of 1/150,000. ...

        Research

        Addressing Race in Pulmonary Function Testing by Aligning Intent and Evidence With Practice and Perception

        The practice of using race or ethnicity in medicine to explain differences between individuals is being called into question because it may contribute to biased medical care and research that perpetuates health disparities and structural racism. ...

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