The Horizon2020 LifeCycle Project is a cross-cohort collaboration which brings together data from multiple birth cohorts from across Europe and Australia to facilitate studies on the influence of early-life exposures on later health outcomes. A major product of this collaboration has been the establishment of a FAIR (findable, accessible, interoperable and reusable) data resource known as the EU Child Cohort Network. Here we focus on the EU Child Cohort Network's core variables. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

To evaluate current ILF testing practices and to survey users regarding the indications, limitations and perceived clinical benefits of ILF testing. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• June 2013

Developing an effective therapy to overcome carbapenemase-positive Klebsiella pneumoniae (CPKp) is an important therapeutic challenge that must be addressed urgently. Here, we explored a Ca-EDTA combination with aztreonam or ceftazidime-avibactam in vitro and in vivo against diverse CPKp clinical isolates. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• July 2023

A population of neutrophils recruited into cystic fibrosis (CF) airways is associated with proteolytic lung damage, exhibiting high expression of primary granule exocytosis marker CD63 and reduced phagocytic receptor CD16. Causative factors for this population are unknown, limiting intervention. Here we present a laboratory model to characterize responses of differentiated airway epithelium and neutrophils following respiratory infection. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Confirm the generalised IgE-trophic activity of the DTaP vaccine in pre-schoolers and demonstrate similar (albeit transient) effects in infants ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• July 2016

Alexander Anthony Larcombe Kicic A A BScEnv (Hons) PhD BSc (Hons) PhD Team Leader, Respiratory Environmental Health Rothwell Family Fellow; Head, Airway Epithelial Research Anthony.Kicic@telethonkids.org.au Team Leader, Respiratory Environmental ...

• 1. Telethon Kids Institute
• Projects

In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2007
• March 2007

Inert gas washout tests, performed using the single- or multiple-breath washout technique, were first described over 60 years ago. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

HIV exposure is associated with altered lung function in early life, with a vulnerable HIV-exposed uninfected subgroup based on maternal disease severity ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Our data shows that the expression of distinct IFNα subtypes within the tumor microenvironment results in different anti-tumor activities ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

The review will outline evidence of long-term health effects, possible mechanisms linking burn injury to long-term health and current research into burns as a chronic disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

Acinar ventilation inhomogeneity measured by single-breath washout was not associated with structural lung disease on CT ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• May 2019