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        601-612 of 1772 results for 'early life'

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        Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

        Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. ...

        Research

        Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice

        In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression. ...

        Research

        Content Validation of Clinician-Reported Items for a Severity Measure for CDKL5 Deficiency Disorder

        CDKL5 deficiency disorder (CDD) results in early-onset seizures and severe developmental impairments. A CDD clinical severity assessment (CCSA) was previously developed with clinician and parent-report items to capture information on a range of domains. ...

        Research

        Exposomes and metabolic health through a physical activity lens: a narrative review

        In this narrative review, we provide an overview of the role of physical activity as part of differing exposomes (our combined non-genetic exposures from conception onwards) and environmental influences on metabolic health. We discuss 'beneficial' exposomes (green/natural outdoor spaces, sun exposure, healthy diets and features of built environments) that could synergise with physical activity to prevent metabolic dysfunction, particularly that related to lifestyle diseases of obesity, type 2 diabetes and metabolic syndrome. ...

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        BEAT CF pulmonary exacerbations core protocol for evaluating the management of pulmonary exacerbations in people with cystic fibrosis

        Cystic fibrosis (CF) is a rare, inherited, life-limiting condition predominantly affecting the lungs, for which there is no cure. The disease is characterized by recurrent pulmonary exacerbations (PEx), which are thought to drive progressive lung damage. Management of these episodes is complex and generally involves multiple interventions targeting different aspects of disease. The emergence of innovative trials and use of Bayesian statistical methods has created renewed opportunities for studying heterogeneous populations in rare diseases. ...

        Research

        SMS4Dads

        Amy Tess Jack Finlay-Jones Fletcher Brett AFJ TF JB BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) BPsych, PhD BPsych (Hons) Head, Early Neurodevelopment & Mental Health; Healthway WA Senior Research Fellow Research Officer Research ...

        Research

        Functioning, participation, and quality of life in children with intellectual disability: an observational study

        To investigate associations between functioning, community participation, and quality of life (QoL) and identify whether participation mediates the effects of functioning on QoL. ...

        Research

        CFC Report

        Download Investigators: Cate Taylor, Daniel Christensen Partners: Tasmanian Early Years Foundation The Tasmanian Government has made a significant commitment in recent years to ensure children have the best possible start in life. However, the cycle ...

        Research

        Precision pathways for young children at risk of Neurodevelopmental Disorders: Early identification and adaptive intervention starting from the prenatal period

        Amy Andrew Carol Deborah Gail Helen Jenny Kandice Martyn Finlay-Jones Whitehouse Watch and listen to Andrew Bower Strickland Alvares Leonard Downs Varcin Symons AFJ AJ C DH GA HM JA KJ MS BPsych(Hons), MPsych(Clinical), MHealthEcon, PhD (Clin Psych) ...

        Research

        Initial Validation and Reliability of the CDKL5 Deficiency Disorder Hand Function Scale (CDD-Hand)

        Pathogenic variants in the CDKL5 gene result in CDKL5 deficiency disorder (CDD), which is characterized by early-onset epilepsy, severe developmental delay, and often, cortical visual impairment. Validated clinical outcome measures are needed for future clinical trials to be successful. This study aimed to adapt the Rett Syndrome Hand Function Scale for CDKL5 deficiency disorder and evaluate its feasibility, acceptability, content validity, and reliability. ...

        Research

        Kindy Readiness Project

        Desiree Jackie Lisa Susan Silva Davis Gibson Prescott DS JD LG SL MBBS, FRACP, MPH, PhD BSc (Hons) BA (Hons), MPsych, PhD MBBS BMedSci PhD FRACP Co-Head, The ORIGINS Project Co-Head, The ORIGINS Project Research Fellow, The ORIGINS Project Honorary ...

        Research

        Innate Immune Training for Prevention of Recurrent Wheeze in Early Childhood

        Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

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