In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live organisms ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• August 2010

Respiratory syncytial virus (RSV) and influenza are important causes of disease in children and adults. In Australia, information on the burden of RSV in adults is particularly limited. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

We aimed to describe case of Influenza associated encephalitis/encephalopathy identified by the Australian Childhood Encephalitis study ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

The review built a case for extending simple and cost–effective measures to all countries. Had these recommendations been put into action, significant... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• September 2014

Neisseria meningitidis is a leading cause of meningitis and septicaemia, but a broadly-protective vaccine against endemic serogroup B disease is not licensed... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012

Review and highlight of the significant advances made towards vaccine development and understanding of the immunology of otitis media ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Pat Tom Jonathan Holt Snelling Carapetis AM PG T JR PhD, DSc, FRCPath, FRCPI, FAA BMBS DTMH GDipClinEpid PhD FRACP AM MBBS FRACP FAFPHM PhD FAHMS Emeritus Honorary Researcher Head, Infectious Disease Implementation Research Executive Director; Head, ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Human adenosine deaminases (ADAs) modulate the immune response: ADA1 via metabolizing adenosine, a purine metabolite that inhibits pro-inflammatory and Th1 cytokine production, and the multi-functional ADA2, by enhancing T-cell proliferation and monocyte differentiation. Newborns are relatively deficient in ADA1 resulting in elevated plasma adenosine concentrations and a Th2/anti-inflammatory bias compared to adults. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Most COVID-19 vaccines are designed to elicit immune responses, ideally neutralizing antibodies (NAbs), against the SARS-CoV-2 spike protein. Several vaccines, including mRNA, adenoviral-vectored, protein subunit and whole-cell inactivated virus vaccines, have now reported efficacy in phase III trials and have received emergency approval in many countries. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

For millennia, Aboriginal people's ways of knowing, doing and being were shared through art, song, and dance. Colonisation silenced these ways, affecting loss of self-determination for Aboriginal people. Over the past decade in Australia, hip-hop projects have become culturally appropriate approaches for health promotion.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Samantha Christopher Valerie Carla Carlson Blyth Swift Puca SC CC VS CP BSc MPH PhD MBBS (Hons) DCH FRACP FRCPA PhD BSc, MPH, MIDI Senior Research Officer Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases ...

• 1. Telethon Kids Institute
• Projects

Asha Jonathan Marianne Tim Bowen Carapetis AM Mullane Barnett AC JR MM TB BA MBBS DCH FRACP PhD GAICD OAM AM MBBS FRACP FAFPHM PhD FAHMS BSc (OT) PhD Head, Healthy Skin and ARF Prevention Executive Director; Head, Strep A Translation; Co-Founder of ...

• 1. Telethon Kids Institute
• Projects