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        Characteristics of TCR Repertoire Associated With Successful Immune Checkpoint Therapy Responses

        Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

        Research

        Systematic assessment of tissue dissociation and storage biases in single-cell and single-nucleus RNA-seq workflows

        Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biase ...

        Research

        COPD-related modification to the airway epithelium permits intracellular residence of nontypeable haemophilus influenzae

        Our findings indicate that COPD, cigarette smoke and macrolide antibiotics potentiate the susceptibility to persistent intracellular NTHi ...

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        Methylome-wide association study of central adiposity implicates genes involved in immune and endocrine systems

        We conducted a methylome-wide association study to examine associations between DNA methylation in whole blood and central adiposity and body fat distribution, measured as waist circumference, waist-to-hip ratio and waist-to-height ratio adjusted for body mass index, in 2684 African-American adults in the Atherosclerosis Risk in Communities study. ...

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        Durvalumab with first-line chemotherapy in previously untreated malignant pleural mesothelioma (DREAM): a multicentre, single-arm, phase 2 trial with a safety run-in

        There is a strong unmet need to improve systemic therapy in mesothelioma. Chemotherapy with cisplatin and pemetrexed improves survival in malignant pleural mesothelioma, and immune checkpoint inhibitors are an emerging treatment in this disease. We aimed to evaluate the activity of durvalumab, an anti-PD-L1 antibody, given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced malignant pleural mesothelioma. ...

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        Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability

        In a well-defined cohort of adolescents, we found non-alcoholic fatty liver disease to be associated with decreased cardiorespiratory fitness, independent of BMI ...

        Research

        Validation of the Dutch version of the Multidimensional Adolescent Functioning Scale (MAFS)

        The Multidimensional Adolescent Functioning Scale (MAFS) is a 23-item, self-report questionnaire assessing psychosocial functioning in adolescents aged 12-17 years. It captures three domains of functioning: 'general functioning', 'family-related functioning', and 'peer-related functioning'. The original English version has good psychometric properties. The aim of the current paper was to translate the MAFS to Dutch and to investigate the psychometric properties of this translation. ...

        Research

        Structural determinants of long term functional outcomes in young children with cystic fibrosis

        Chest CT identifies children at an early age who have adverse long-term outcomes ...

        Research

        Clinical description and outcomes of Australian children with invasive group a streptococcal disease

        Invasive group A streptococcal infection in Australian children is frequently severe and has a high long-term morbidity burden ...

        Research

        Exploring enablers and barriers to accessing health services after a fall among people with intellectual disability

        There is an urgent need to develop high-quality falls prevention services for older adults with intellectual disability ...

        Research

        Parents’ experience and psychoeducation needs when supporting a young person who self-harms

        The study highlights the need for support for parents and carers of young people who engage in self-harm ...

        Research

        Combining whole-school and targeted programs for the reduction of bullying victimization: A randomized, effectiveness trial

        The current effectiveness trial evaluated the combination of a whole-school program designed to prevent bullying perpetration and victimization ...

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