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        Clinical Implications of Minimal Residual Disease Detection in Infants With KMT2A-Rearranged Acute Lymphoblastic Leukemia Treated on the Interfant-06 Protocol

        Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide). ...

        Research

        Brief Report: Facial Asymmetry and Autistic-Like Traits in the General Population

        Atypical facial morphology, particularly increased facial asymmetry, has been identified in some individuals with Autism Spectrum Conditions (ASC). Many cognitive, behavioural and biological features associated with ASC also occur on a continuum in the general population. ...

        Research

        Defining the fetal origin of MLL-AF4 infant leukemia highlights specific fatty acid requirements

        Infant MLL-AF4-driven acute lymphoblastic leukemia (ALL) is a devastating disease with dismal prognosis. A lack of understanding of the unique biology of this disease, particularly its prenatal origin, has hindered improvement of survival. We perform multiple RNA sequencing experiments on fetal, neonatal, and adult hematopoietic stem and progenitor cells from human and mouse. ...

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        The detection of bile acids in the lungs of paediatric cystic fibrosis patients is associated with altered inflammatory patterns

        Our work has identified a clinically relevant host-derived factor that may participate in shaping early events in the aetiology of CF respiratory disease ...

        Research

        House Dust Mite Allergens: New Discoveries and Relevance to the Allergic Patient

        Recent findings on house dust allergens and their contribution to knowledge that will significantly impact current and future allergy treatments are appraised ...

        Research

        Quantitative assessment of airway dimensions in young children with cystic fibrosis lung disease using chest computed tomography

        To evaluate lung disease progression using AA dimensions on chest CT over 2-years in young CF patients longitudinally and compare to disease controls. ...

        Research

        Elizabeth Usher Memorial Lecture: Rethinking the clinical pathway for autism spectrum disorder and challenging the status quo

        The aim of the paper is to outline the future of early identification and intervention of ASD and the research goals to be addressed to achieve this vision. ...

        Research

        Premedication with salbutamol prior to surgery does not decrease the risk of perioperative respiratory adverse events in school-aged children

        Premedication with salbutamol to children prior to their surgery did not reduce their risk of Perioperative respiratory adverse events ...

        Research

        A collaborative yarn on qualitative health research with Aboriginal communities

        In this paper, we seek to provide guidance for researchers who are new to undertaking research with Aboriginal and Torres Strait Islander communities ...

        Research

        Differences in stroke risk and cardiovascular mortality for Aboriginal and other Australian patients with atrial fibrillation

        Stroke risk and cardiovascular mortality are markedly higher for Aboriginal than non-Aboriginal patients with atrial fibrillation, particularly for patients under 60 ...

        Research

        Does the Risk Outweigh the Benefits? Adolescent Responses to Completing Health Surveys

        Self-reported experiences of adolescents in population-based samples when completing health-related surveys on topics with varying potential for evoking distres ...

        Research

        Haptic Exploratory Procedures of Children and Youth with and without Cerebral Palsy

        Children with cerebral palsy performed similar haptic exploratory procedures as their typical development peers ...

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