Immunotherapies have revolutionized cancer treatment. In particular, immune checkpoint therapy (ICT) leads to durable responses in some patients with some cancers. However, the majority of treated patients do not respond. Understanding immune mechanisms that underlie responsiveness to ICT will help identify predictive biomarkers of response and develop treatments to convert non-responding patients to responding ones. ICT primarily acts at the level of adaptive immunity. The specificity of adaptive immune cells, such as T and B cells, is determined by antigen-specific receptors. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

Early infancy oral vitamin D supplementation does not appear to reduce the development of early childhood allergic disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Systematic comparison of recovered cell types and their transcriptional profiles across the workflows has highlighted protocol-specific biase ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Chest CT identifies children at an early age who have adverse long-term outcomes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

Treatment with fluoxetine compared with placebo resulted in significantly lower scores for obsessive-compulsive behaviors at 16 weeks ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

This review explores computational strategies to yield biological insight into the processes involved in the immunotherapeutic response ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

There is a high incidence of vaccine-preventable morbidity post-allogeneic haematopoietic stem cell transplantation in West Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Population-based primary prevention of ARF through sore throat management may be effective in well-resourced settings like New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

To assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• June 2018

Consensus recommendations are outlined to direct preschool device design, test performance, and data analysis for the MBW technique ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• March 2018

Nonrecurrent risk of stillbirth, Preterm birth, and small for gestational age after exposure to one or more of these complications in a previous pregnancy ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Children with acute respiratory tract infection (ARTI) frequently exhibit virus-virus codetection, yet the clinical significance of ARTI remains contentious. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017