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        Broad-spectrum in vitro activity of macrophage infectivity potentiator inhibitors against Gram-negative bacteria and Leishmania major

        The macrophage infectivity potentiator (Mip) protein, which belongs to the immunophilin superfamily, is a peptidyl-prolyl cis/trans isomerase (PPIase) enzyme. Mip has been shown to be important for virulence in a wide range of pathogenic microorganisms. ...

        Research

        Dysphagia in laryngomalacia: a prospective cohort study

        Dysphagia is an under recognised co-morbidity in patients with laryngomalacia. Its rate is variable reported in the literature. We aim to describe the incidence of dysphagia in laryngomalacia, the effect of interventions on this, and the period it persists in these infants. ...

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        Radiomics-A new age of presurgical assessment to improve outcomes in pediatric neuro-oncology

        Citation: Valvi S, Hansford JR. Radiomics-A new age of presurgical assessment to improve outcomes in pediatric neuro-oncology. Neuro Oncol. 2022;24(6):995-6. Keywords: Ependymoma; neurology ...

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        Searching for a technology-driven acute rheumatic fever test: the START study protocol

        The absence of a diagnostic test for acute rheumatic fever (ARF) is a major impediment in managing this serious childhood condition. ARF is an autoimmune condition triggered by infection with group A Streptococcus. ...

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        Excess respiratory mortality and hospitalizations associated with influenza in Australia, 2007-2015

        Influenza is the most common vaccine-preventable disease in Australia, causing significant morbidity and mortality. We assessed the burden of influenza across all ages in terms of influenza-associated mortality and hospitalizations using national mortality, hospital-discharge and influenza surveillance data. ...

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        The role and therapeutic implications of T cells in cancer of the lung

        This review examines the role of T cells in lung cancer, discussing the direction and clinical significance of current and future immunotherapeutic strategies ...

        Research

        novel small molecule that kills a subset of MLL-rearranged leukemia cells by inducing mitochondrial dysfunction

        This study thus identified a novel small molecule that rapidly kills MLL-rearranged leukemia cells by targeting a metabolic vulnerability ...

        Research

        B Part of It School Leaver protocol: an observational study to assess the impact of a meningococcal serogroup B vaccine programme on carriage of Neisseria meningitidis

        This study will assess the impact of MenB vaccine (4CMenB) on carriage prevalence in school leavers in South Australia ...

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        Still keen and committed: piloting an instrument for identifying positive veteran teachers

        Initial findings suggest the potential of the instrument in helping identifying positive veteran teachers within systems, as well as the voracity of the research approach ...

        Research

        Call for a national sore throat guideline

        Australia needs a single national pharyngitis guideline to assist in providing rational, consistent and timely antibiotic treatment to patients at high risk of ARF ...

        Research

        Innate immune activation occurs in acute food protein–induced enterocolitis syndrome reactions

        Food reactions in food protein–induced enterocolitis syndrome are predominantly underpinned by activation of the innate immune system ...

        Research

        Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

        These data suggest that altered methylation of CpG loci within SLC6A4 may provide a robust marker of adiposity across the life course ...

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