The emergence of multi-drug resistant (MDR) bacteria is recognised today as one of the greatest challenges to public health. As traditional antimicrobials are becoming ineffective and research into new antibiotics is diminishing, a number of alternative treatments for MDR bacteria have been receiving greater attention. Bacteriophage therapies are being revisited and present a promising opportunity to reduce the burden of bacterial infection in this post-antibiotic era. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Ankle and hip power generation as a propulsion strategy during the late stance/early swing phases of walking and running in typically developing children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

We hypothesized that allergic inflammation decreases the level of circulating 25(OH)D and tested this using a mice model of house dust mite (HDM) induced... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Preterm birth and subsequent neonatal ventilatory treatment disrupts development of the hypoxic ventilatory response (HVR). An attenuated HVR has been identified in preterm neonates, however it is unknown whether the attenuation persists into the second year of life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

Stephen Stick SM MB BChir PhD MRCP FRACP Head, P4 Respiratory Health for Kids Head, P4 Respiratory Health for Kids Areas for research expertise: Research Interests; Paediatric respiratory disease; Cystic fibrosis; Respiratory epithelium; Lung ...

• 1. Telethon Kids Institute
• Projects

Research to further improve outcomes for people with CF is dependent upon well characterised, archived and accessible clinical specimens. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• September 2017

Prader-Willi syndrome (PWS) is a rare genetic disorder characterised by neurodevelopmental delays, hyperphagia, difficulties with social communication and challenging behaviours. Individuals require intensive supervision from caregivers which may negatively affect caregiver quality of life. This study used data collected in the Australasian PWS Registry to evaluate associations between child behaviours and caregiver mental well-being. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Authors: Whitehouse AJ, Maybery MT, Hart R, Mattes E, Newnham JP, Sloboda DM, Stanley FJ, Hickey M. Authors notes: Psychoneuroendocrinology. 2010 Sep;35(8):1259-64. Epub 2010 Mar 4. Keywords: Fetal androgen exposure, pragmatic language ability, ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• September 2010

Review of the clinical and biological progress over 50 years in Rett Syndrome ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017