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        Consensus guidelines for antifungal prophylaxis in haematological malignancy and haemopoietic stem cell transplantation, 2021

        Antifungal prophylaxis can reduce morbidity and mortality from invasive fungal disease (IFD). However, its use needs to be optimised and appropriately targeted to patients at highest risk to derive the most benefit. In addition to established risks for IFD, considerable recent progress in the treatment of malignancies has resulted in the development of new 'at-risk' groups. ...

        Research

        Streptococcus pneumoniae and Haemophilus influenzae in paediatric meningitis patients at Goroka General Hospital

        This research presents serotype, antimicrobial susceptibility and outcome data from paediatric meningitis patients prior to introduction of Haemophilus... ...

        Research

        Birth outcomes in Aboriginal mother–infant pairs from the Northern Territory, Australia, who received 23-valent polysaccharide pneumococcal vaccination during pregnancy

        We found a numerically higher rate of preterm births among women who received 23vPPV in pregnancy compared to unvaccinated pregnant women ...

        Research

        Midwives’ attitudes, beliefs and concerns about childhood vaccination: A review of the global literature

        The majority of midwives supported vaccination, although a spectrum of beliefs and concerns emerged ...

        Research

        Exposure to chorioamnionitis alters the monocyte transcriptional response to the neonatal pathogen Staphylococcus epidermidis

        Our findings suggest that prenatal exposure to inflammation may alter the risk of sepsis in preterm infants partly by modulation of monocyte responses to pathogens ...

        Research

        Research priorities for childhood chronic conditions: a workshop report

        Research priorities emphasise a focus on life participation, psychosocial well-being, impact on family and quality of care ...

        Research

        RD-RAP: Beyond rare disease patient registries, devising a comprehensive data and analytic framework

        We introduce and describe the concept of a Rare Disease Registry and Analytics Platform ...

        Research

        Perioperative pediatric tonsillectomy analgesia: A single-center review of practice and cost-effectiveness analysis

        Tonsillectomy is one of the most common pediatric surgeries and results in considerable postoperative pain. Insufficiently managed pain is costly, risks physiological and psychological consequences with multi-modal analgesia widely recommended to minimize opioid-based agents. We determined adherence to multi-modal analgesia guidelines and assessed cost-effectiveness. We undertook a cross-sectional cohort study at a tertiary pediatric institution in Perth, Western Australia, retrospectively identifying selected patients undergoing tonsillectomy over two discrete periods of 6-week duration. ...

        Research

        A Rationale for Change: An Increase in Invasive Pneumococcal Disease in Fully Vaccinated Children

        A review of cases informed a change from a "3 + 0" infant schedule to a "2 + 1" schedule ...

        Research

        Converting the maybes: Crucial for a successful COVID-19 vaccination strategy

        Broad community acceptance of a COVID-19 vaccination will be critical for effectively halting the spread of the virus. In this study, we focus on factors that differentiate those who are undecided from those who are either willing or unwilling to accept a prospective COVID-19 vaccine. An online survey in May 2020 assessed Australian adults' willingness to receive a COVID-19 vaccine (yes, maybe, no). A multinomial logistical regression of responses (N = 1,313) was used to identify correlates of vaccine willingness between the three groups. ...

        Research

        Best practice when working with suicidal behaviour and self-harm in primary care: a qualitative exploration of young people's perspectives

        General practitioners (GPs) have a key role in supporting young people who present with suicidal behaviour/self-harm. However, little is known about young people's opinions and experiences related to GPs' practices for such presentations, and their decisions to disclose suicidal behaviour/self-harm to GPs. Additionally, existing guidelines for the management of suicide risk and/or self-harm have not incorporated young people's perspectives. This study aimed to explore young people's views and experiences related to the identification, assessment and care of suicidal behaviour and self-harm in primary care settings with GPs. ...

        Research

        Optimising a 6-plex tetanus-diphtheria-pertussis fluorescent bead-based immunoassay

        Small volume assays are required for large-scale research studies and in particular paediatric trials, where multiple measures are required from a single sample. Fluorescent bead-based technology (Bioplex/Luminex) allows high through-put and simultaneous quantification of multiple analytes in a single test. This technology uses sets of microspheres, each with a unique spectral address that can be coated with a different antigen of interest. ...

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