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        A novel precision-serology assay for SARS-CoV-2 infection based on linear B-cell epitopes of Spike protein

        The COVID-19 pandemic illustrates the need for serology diagnostics with improved accuracy. While conventional serology based on recognition of entire proteins or subunits thereof has made significant contribution to the antibody assessment space, it often suffers from sub-optimal specificity. Epitope-based, high-precision, serology assays hold potential to capture the high specificity and diversity of the immune system, hence circumventing the cross-reactivity with closely related microbial antigens.  ...

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        Continuous electroencephalography in the intensive care unit: A critical review and position statement from an Australian and New Zealand perspective

        This article aims to critically review the literature on continuous electroencephalography (cEEG) monitoring in the intensive care unit (ICU) from an Australian and New Zealand perspective and provide recommendations for clinicians. Design and review methods: A taskforce of adult and paediatric neurologists, selected by the Epilepsy Society of Australia, reviewed the literature on cEEG for seizure detection in critically ill neonates, children, and adults in the ICU. ...

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        Youth experiences of co-designing a well-being intervention: reflections, learnings and recommendations

        Co-design and youth participatory action research are promising methodologies for increasing youth engagement in well-being interventions. The current study included 10 recent high school graduates employed as youth advisors to co-design a youth-friendly positive psychology intervention targeting the post-school transition. The youth advisors received foundational training in positive psychology, psychological needs theory and emerging adulthood. ...

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        Tracking of activated cTfh cells following sequential influenza vaccinations reveals transcriptional profile of clonotypes driving a vaccine-induced immune response

        A vaccine against influenza is available seasonally but is not 100% effective. A predictor of successful seroconversion in adults is an increase in activated circulating T follicular helper (cTfh) cells after vaccination. However, the impact of repeated annual vaccinations on long-term protection and seasonal vaccine efficacy remains unclear. ...

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        Gene dysregulation in acute HIV-1 infection – early transcriptomic analysis reveals the crucial biological functions affected

        Transcriptomic analyses from early human immunodeficiency virus (HIV) infection have the potential to reveal how HIV causes widespread and lasting damage to biological functions, especially in the immune system. Previous studies have been limited by difficulties in obtaining early specimens. ...

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        Identifying the asthma research priorities of people with asthma, their carers and other stakeholders

        People living with asthma, their carers, clinicians and policymakers are the end-users of research and need research that address their individual healthcare needs. We aimed to understand the research priorities of end-users of asthma research. ...

        Research

        Offshore detention: cross-sectional analysis of the health of children and young people seeking asylum in Australia

        To describe the health and well-being of children and young people (CYP) seeking asylum subjected to Australia's immigration policy of indefinite mandatory detention on Nauru. ...

        Research

        Population-based assessment of cardiovascular complications of rheumatic heart disease in Fiji: a record-linkage analysis

        To determine population-based rates of non-fatal complications of rheumatic heart disease (RHD). ...

        Research

        Frankenstein Cas9: engineering improved gene editing systems

        The discovery of CRISPR-Cas9 and its widespread use has revolutionised and propelled research in biological sciences. ...

        Research

        Healthy Environments and Lives (HEAL): Australian research network in human health and environmental change

        The HEAL Network aims to strengthen the Australian health system and community resilience to climate change, extreme events, and environmental degradation. ...

        Research

        Celebrating the lived experience of socio-economic disadvantage in the public health workforce

        Joelie Mandzufas JM BCom BHSc GCHELT Project Coordinator Joelie.mandzufas@telethonkids.org.au PhD Student Joelie Mandzufas is a PhD student with the University of Western Australia, co-located with the Food and Nutrition Research team at Telethon ...

        Research

        The health-related quality of life of lung cancer patients with EGFR-TKI-related skin adverse drug reactions and its relationship with coping style and self-management

        The status and associated factors of the health-related quality of life of non-small-cell lung cancer patients under targeted anti-cancer therapy have not been investigated. Self-management and coping style have been proven to be closely related to patients’ health-related quality of life. ...

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