Childhood is a critical period of immune development. During this time, naïve CD4 T cells undergo programmed cell differentiation, mediated by epigenetic changes, in response to external stimuli leading to a baseline homeostatic state that may determine lifelong disease risk. However, the ontogeny of epigenetic signatures associated with CD4 T cell activation during key developmental periods are yet to be described. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• February 2023

Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice is currently limited to in vitro, animal and observational human case-series data, with no previous randomized controlled trials (RCTs). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

Impetigo is a contagious skin disease caused by Staphylococcus aureus and Streptococcus pyogenes. Without treatment, impetigo may be recurrent, develop into severe disease, or have serious, life-threatening sequelae. Standard treatment consists of topical or systemic antibiotic therapy (depending on severity), however, due to antibiotic resistance some therapies are increasingly ineffective. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

Acute rheumatic fever and rheumatic heart disease disproportionately affect Aboriginal and Torres Strait Islander people in Australia, with devastating impacts on morbidity, mortality and community wellbeing. Research suggests that general practitioners and primary care staff perceive insurmountable barriers to improving clinical outcomes, including the need for systemic change outside their scope of practice. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

The effects of maternal alcohol-use disorder are experienced by the majority of exposed children rather than a vulnerable subgroup of this population ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

The aim of the task force was to provide technical recommendations regarding oscillometry measurement ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

Brad Carol Glenn Carrington Steve Farrant Michie Pearson Shepherd Zubrick Related Projects Elder Researchers Contact BM C G CCJ SR If you would like more information or to become involved in the project, please get in touch with : Carol Michie T: ( ...

• Telethon Kids Institute
• Our research
• Brain and Behaviour
• Mental Health and Youth Program
• Aboriginal Health and Wellbeing

Our findings illustrate the vulnerabilities of children born to foreign women from low and middle-income countries ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• August 2019

Prospective longitudinal birth cohort data was used to examine the association between peer aggression at 14yrs and mental health and substance use at 17yrs... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia, and it strongly... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• October 2012

Barrett's esophagus is an increasingly common disease that is strongly associated with reflux of stomach acid and usually a hiatus hernia,... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• September 2012