In the Saline Hypertonic in Preschoolers (SHIP) study, inhaled 7% hypertonic saline improved the lung clearance index in children aged 3-6 years with cystic fibrosis, but it remained unclear whether improvement is also seen in structural lung disease. We aimed to assess the effect of inhaled hypertonic saline on chest CT imaging in children aged 3-6 years with cystic fibrosis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Structural and functional defects within the lungs of children with cystic fibrosis (CF) are detectable soon after birth and progress throughout preschool years often without overt clinical signs or symptoms. By school age, most children have structural changes such as bronchiectasis or gas trapping/hypoperfusion and lung function abnormalities that persist into later life. Despite improved survival, gains in forced expiratory volume in one second (FEV1) achieved across successive birth cohorts during childhood have plateaued, and rates of FEV1 decline in adolescence and adulthood have not slowed. This suggests that interventions aimed at preventing lung disease should be targeted to mild disease and commence in early life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

SHIP-CT showed that 48-week treatment with inhaled 7% hypertonic saline (HS) reduced airway abnormalities on chest CT using the manual PRAGMA-CF method relative to isotonic saline (IS) in children aged 3-6 years with cystic fibrosis (CF). An algorithm was developed and validated to automatically measure bronchus and artery (BA) dimensions of BA-pairs on chest CT. Aim of the study was to assess the effect of HS on bronchial wall thickening and bronchial widening using the BA-analysis. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• May 2023

Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014

Hayley Karen Christian Lombardi HC KL BSc (1st Class Hons), PhD W.Aust. BHSc (Hons), PhD Program Head, Healthy Behaviours and Environments; National Heart Foundation Future Leader Fellow Research Fellow 08 6319 1040 6319 1477 hayley.christian@ ...

• 1. Telethon Kids Institute
• Projects

Many of the mental health issues that women develop earlier in life are chronic at the time of conception, during pregnancy and at birth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• July 2019

This review attempts to highlight migration-specific and cell-extracellular matrix (ECM) aspects of repair used by epithelial cells ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

This report presents the evaluation findings of headspace, a service to improve the mental health and social and emotional wellbeing of young people ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Family-based lifestyle interventions for children/adolescents with severe levels of obesity are numerous, but evidence indicates programs fail to elicit short- or longer-term weight loss outcomes. Families with lived experience can provide valuable insight as we strive to improve outcomes from programs. Our aim was to explore elements that families desired in a program designed to treat severe levels of obesity in young people. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Melissa Gail Jenny Andrew Licari Alvares Downs Whitehouse Watch and listen to Andrew ML GA JA AJ PhD PhD BApplSci (physio) MSc PhD PhD Senior Research Fellow Senior Research Fellow Program Head, Development and Disability Angela Wright Bennett ...

• 1. Telethon Kids Institute
• Projects

A prior episode of deliberate self-harm (DSH) is one of the strongest predictors of future completed suicide. Identifying antecedents of DSH may inform strategi ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• October 2010

This study identified possible antecedents of teenage pregnancy using linked data from administrative sources to create a 14-year follow-up from a cross-sect... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• February 2010