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        Small nucleolar RNA networks are up-regulated during human anaphylaxis

        Anaphylaxis is a severe, potentially life-threatening allergic reaction driven primarily by the activation of mast cells. We still fail to understand factors underlying reaction severity. Furthermore, there is currently no reliable diagnostic test to confirm anaphylaxis in the emergency department. ...

        Research

        Association between interpregnancy interval and hypertensive disorders of pregnancy: Effect modification by maternal age

        Short and long interpregnancy intervals (IPI) are associated with increased risk of hypertensive disorders of pregnancy, yet whether this association is modified by maternal age remains unclear. We examined if the association between IPI and hypertensive disorders of pregnancy varies by maternal age at birth prior to IPI. ...

        Research

        We won't find what we don't look for: Identifying barriers and enablers of chronic wet cough in Aboriginal children

        Key barriers to effective management of chronic wet cough are limited training in chronic wet cough management combined with competing complexities ...

        Research

        IgG3 + B cells are associated with the development of multiple sclerosis

        We have identified previously uncharacterised subsets of IgG3 + B cells and shown them to correlate with autoimmune attacks on the central nervous system ...

        Research

        COPD-related modification to the airway epithelium permits intracellular residence of nontypeable haemophilus influenzae

        Our findings indicate that COPD, cigarette smoke and macrolide antibiotics potentiate the susceptibility to persistent intracellular NTHi ...

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        Symptom-related distress among indigenous Australians in specialist end-of-life care: Findings from the multi-jurisdictional palliative care outcomes collaboration data

        These findings provide reassurance of reasonable equivalence of end-of-life outcomes for Indigenous patients who have been accepted for specialist palliative care ...

        Research

        Immune function during early adolescence positively predicts adult facial sexual dimorphism in both men and women

        Our results support a fundamental assumption that facial sexual dimorphism is an indicator of immune function during the development of facial sexual dimorphism ...

        Research

        Associations between negative life experiences and the mental health of trans and gender diverse young people in Australia: Findings from Trans Pathways

        The current results highlight the urgent need for better mental health care and provide insight into areas for targeted mental health interventions ...

        Research

        Decreased Physical Working Capacity in Adolescents With Nonalcoholic Fatty Liver Disease Associates With Reduced Iron Availability

        In a well-defined cohort of adolescents, we found non-alcoholic fatty liver disease to be associated with decreased cardiorespiratory fitness, independent of BMI ...

        Research

        Machine learning and clinical epigenetics: a review of challenges for diagnosis and classification

        We now have a growing number of epigenetic alterations in disease, and this offers a chance to increase sensitivity and specificity of future diagnostics and therapies ...

        Research

        The Wittenoom legacy

        The legacy of Wittenoom has extended beyond the mine and the town, and is still evident more than 50 years after the closure of the mine ...

        Research

        The Brain Basis of Comorbidity in Neurodevelopmental Disorders

        This review discusses early brain development and the etiological factors that may give rise to atypical developmental trajectories, along with neuroimaging insights ...

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