Pre-existing pathogen-specific memory T cell responses can contribute to multiple adverse outcomes including autoimmunity and drug hypersensitivity. How the specificity of the T cell receptor (TCR) is subverted or seconded in many of these diseases remains unclear. Here, we apply abacavir hypersensitivity (AHS) as a model to address this question because the disease is linked to memory T cell responses and the HLA risk allele, HLA-B*57:01, and the initiating insult, abacavir, are known. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

We derived a simple ordinary differential equation-based model using Michaelis–Menten Kinetics to process the microarray data ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

With the importance of early childhood development more recognized by the international society, low-cost and cross-culturally comparable measures of early childhood development is in great demand, both in China and worldwide. In this study, we aim to test the psychometrics of the Chinese version of The Early Human Capability Index (eHCI), which is designed as a measurement for school readiness in large population. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• June 2020

Couples can be supported in these key areas to strengthen their relationship to serve as a source of resilience for families with a child with ASD ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Couples should be supported to strengthen communication processes and work in partnership to raise their child with ASD through family-centred interventions ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

The effect that attending a consumer and community participation had on their awareness of and attitudes to consumer and community involvement ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

To describe the changes in end-expiratory lung volume and ventilation inhomogeneities during spells in three children with Tetralogy of Fallot. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

Experimental studies suggest that exposures may impact respiratory health across generations via epigenetic changes transmitted specifically through male germ cells. Studies in humans are, however, limited. We aim to identify epigenetic marks in offspring associated with father's preconception smoking. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• August 2023

Dysphagia, one of the most common complications in head and neck cancer (HNC) treated with radiotherapy, can severely affect patients’ quality of life. Currently, because no “gold standard” treatment exists, swallowing exercise remains the main rehabilitation strategy for dysphagia. However, patients’ compliance with long-term swallowing exercise is only 40%, thus, greatly compromising outcomes. This article aims to analyze thefactors influencing swallowing exercise compliance in patients with HNC and explains strategies developed to date for improved rehabilitation outcomes. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Helen Jenny Keely Leonard Downs Bebbington HM JA KB MBChB MPH BApplSci (physio) MSc PhD MClinPsych/PhD Principal Research Fellow Program Head, Development and Disability McCusker Postdoctoral Research Fellow in Type 1 Diabetes +61 419 956 946 08 ...

• 1. Telethon Kids Institute
• Projects

Optimal mental health in the pre-conception, pregnancy and postpartum periods is important for both maternal and infant wellbeing. Few studies, however, have focused on Indigenous women and the specific risk and protective factors that may prompt vulnerability to perinatal mental disorders in this culturally diverse population. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

The use of this core set of data will facilitate the pooling of psychopathological and neurobiological data into large datasets ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020