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        Burden of skin disease in two remote primary healthcare centres in northern and central Australia

        Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities ...

        Research

        Lessons learnt during the COVID-19 pandemic: Why Australian schools should be prioritised to stay open

        In 2020, school and early childhood educational centre (ECEC) closures affected over 1.5 billion school-aged children globally as part of the COVID-19 pandemic response. Attendance at school and access to ECEC is critical to a child's learning, well-being and health. School closures increase inequities by disproportionately affecting vulnerable children. Here, we summarise the role of children and adolescents in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) transmission and that of schools and ECECs in community transmission and describe the Australian experience. ...

        Research

        Clindamycin adjunctive therapy for severe Staphylococcus aureus treatment evaluation (CASSETTE)-an open-labelled pilot randomized controlled trial

        Combination antibiotic therapy with an antitoxin agent, such as clindamycin, is included in some guidelines for severe, toxin-mediated Staphylococcus aureus infections. The evidence to support this practice is currently limited to in vitro, animal and observational human case-series data, with no previous randomized controlled trials (RCTs). ...

        Research

        Veliparib Is an Effective Radiosensitizing Agent in a Preclinical Model of Medulloblastoma

        Medulloblastoma is the most common malignant childhood brain tumor, and 5-year overall survival rates are as low as 40% depending on molecular subtype, with new therapies critically important. As radiotherapy and chemotherapy act through the induction of DNA damage, the sensitization of cancer cells through the inhibition of DNA damage repair pathways is a potential therapeutic strategy. ...

        Research

        “Coronavirus Changed the Rules on Everything”: Parent Perspectives on How the COVID‐19 Pandemic Influenced Family Routines, Relationships and Technology Use in Families with Infants

        This study explores how the first wave of the COVID‐19 pandemic influenced family routines, relationships and technology use (smartphones and tablet computers) among families with infants. Infancy is known to be an important period for attachment security and future child development, and a time of being susceptible to changes within and outside of the family unit. ...

        Research

        Study protocol of a multicentre, randomised, controlled trial evaluating the effectiveness of probiotic and peanut oral immunotherapy in inducing desensitisation or tolerance in children with peanut allergy compared with oral immunotherapy

        Peanut allergy is the the most common cause of life-threatening food-induced anaphylaxis. There is currently no effective long-term treatment. There is a pressing need for definitive treatments that improve the quality of life and prevent fatalities. ...

        Research

        Severe adverse events following benzathine penicillin G injection for rheumatic heart disease prophylaxis: cardiac compromise more likely than anaphylaxis

        These results indicate that anaphylaxis is not a major cause of adverse reactions to benzathine penicillin G ...

        Research

        The NICE-GUT trial protocol: A randomised, placebo controlled trial of oral nitazoxanide for the empiric treatment of acute gastroenteritis among Australian Aboriginal children

        Diarrhoeal disease is the second leading cause of death in children under 5 years globally, killing 525 000 annually. Australian Aboriginal and Torres Strait Islander (hereafter Aboriginal) children suffer a high burden of disease. ...

        Research

        Chemotherapy increases amenability of surgical resection in congenital glioblastoma

        Brain tumors presenting in infancy, especially during the first 6 months of life. ...

        Research

        Pediatric meningioma: Current approaches and future direction

        With improvement in leukemia therapy, central nervous system (CNS) tumors are the leading cause of cancer mortality in children and the most expensive... ...

        Research

        Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple

        Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21We performed... ...

        Research

        P2X7 receptor-mediated killing of an intracellular parasite, Toxoplasma gondii, by human and murine macrophages

        The P2X7R is highly expressed on the macrophage cell surface, and activation of infected cells by extracellular ATP has been shown to kill intracellular bacte ...

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