Group A Streptococcus (GAS) is a Gram-positive bacterial pathogen that causes an array of infectious diseases in humans. Accumulating clinical evidence suggests that proinflammatory interleukin (IL)-1beta signaling plays an important role in GAS disease progression. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• August 2021

In the absence of an established gold standard, an understanding of the testing cycle from individual exposure to test outcome report is required to guide the correct interpretation of SARS-CoV-2 reverse transcriptase real-time polymerase chain reaction (RT-PCR) results and optimise the testing processes. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Safe, highly curative, short course, direct acting antiviral (DAA) therapies are now available to treat chronic hepatitis C. DAA therapy is freely available to all adults chronically infected with the hepatitis C virus (HCV) in Australia. If left untreated, hepatitis C may lead to progressive hepatic fibrosis, cirrhosis and hepatocellular carcinoma. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• October 2020

The aim of this study was to understand the challenges experienced by families obtaining a diagnosis and therapy for developmental coordination disorder (DCD). Parents of 435 children aged 4-18 years with persistent motor difficulties consistent with a diagnosis of DCD completed an online survey. Diagnostic timeline and diagnostic label/s received were examined, along with therapies accessed. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

In this letter, the authors respond to the commentary on Chong et al. “How many infants are temperamentally difficult?”; by correcting errors, & then... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• October 2015

In addition to its role in blocking TH2 effector activation in the late-phase allergic response, IL-10 is a known IgG1 switch factor ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Student bullying behaviours are a significant social issue in schools worldwide. Whilst school staff have access to quality bullying prevention interventions, schools can face significant challenges implementing the whole-school approach required to address the complexity of these behaviours. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• September 2022

Despite education about the risks of excessive sun exposure, teenagers in Australia are sun-seeking, with sunburn common in summer. Conversely, some regular (time-limited) exposure to sunlight (that avoids sunburn) is necessary for vitamin D and healthy bones and other molecules important for immune and metabolic health. New interventions are thus required to better support teenagers to make healthy and balanced decisions about their sun behaviors. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Diagnosis of chronic disease in a child can result in unresolved grief (UG) in parents. This study aimed to evaluate the efficacy of psychological insight-oriented therapy (IOT) as a treatment for UG compared to disease related education in parents of children with cystic fibrosis. Sequence of delivery, first IOT then disease related education (or vice versa) was also examined, to let all participants experience both interventions. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• April 2022

Evidence suggests that individuals with autism spectrum disorder have increased rates of co-occurring psychosis and/or bipolar disorder. Considering the peak age of onset for psychosis and bipolar disorder occurs in adulthood, we investigated the co-occurrence of these disorders in adults with autism. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• March 2022

Atopic diseases are the most common chronic conditions of childhood. The apparent rise in food anaphylaxis in young children over the past three decades is of particular concern, owing to the lack of proven prevention strategies other than the timely introduction of peanut and egg. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

Childhood obesity is one of the most serious public health challenges of the 21st century and is affected not only by individual choice but also by societal and environmental influences. Childhood obesity is higher in children living in regional and remote compared with major cities, in one-parent families and for those with a disability. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021