This article discusses the relationships between gut colonization & inflammatory noncommunicable diseases, in regards to their treatment and prevention. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• November 2015

Free NE activity is deleterious for epithelial homeostasis and support the hypothesis that proteases in the airway contribute to CF structural lung disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

In this review, we consider recent evidence regarding hypoxia and sterile inflammation in cystic fibrosis airways ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

Better understanding of evolution of lung function in infants with cystic fibrosis... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• July 2011

Two lytic double-stranded DNA (dsDNA) bacteriophages, belonging to the family Herelleviridae, were isolated from wastewater in Western Australia. Biyabeda-mokiny 2 appears to belong to the genus Kayvirus, and Koomba-kaat 1 to Silviavirus. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• December 2022

An estimated 3.5%-5.9% of the global population live with rare diseases, and approximately 80% of these diseases have a genetic cause. Rare genetic diseases are difficult to diagnose, with some affected individuals experiencing diagnostic delays of 5-30 years. Next-generation sequencing has improved clinical diagnostic rates to 33%-48%. In a majority of cases, novel variants potentially causing the disease are discovered.  ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2024
• January 2024

We hope that through earlier diagnosis and treatment of muscle weakness during sleep, we can prevent future lung failure in children with neuromuscular disorders. ...

• 1. Telethon Kids Institute
• Projects

The method outlined in this article is a customization of the whole exhaust exposure method generated by Mullins et al. (2016) using reprogrammed primary human airway epithelial cells as described by Martinovich et al. (2017). It has been used successfully to generate recently published data (Landwehr et al. 2021). The goal was to generate an exhaust exposure model where exhaust is collected from a modern engine, real-world exhaust concentrations are used and relevant tissues exposed to assess the effects of multiple biodiesel exposures. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• October 2021

Our data illustrate that rhinovirus infection is capable of infecting upper and lower airway epithelial cells, driving cell death and inflammation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• December 2019

Including immediate implications for pregnancy complications, increasing evidence implicates maternal obesity having a major impact on long term child health. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• January 2017

Modulation of ASL pH has been proposed as a therapy for CF. However, evidence that ASL pH is reduced in CF is limited and conflicting. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• November 2017

Determinants of culture success through retrospective analysis of a program of routinely brushing children with Cystic Fibrosis airway disease ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• November 2014