This report provides detailed characterization of carcinoma of unknown primary (CUP) in a young child and in the absence of defined therapeutic guidelines for pediatric CUP, the successful treatment strategy described should be considered for similar cases. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

Streptococcus pyogenes is a leading cause of infection-related morbidity and mortality. A reinvigorated vaccine development effort calls for new clinically relevant human S pyogenes experimental infection models to support proof of concept evaluation of candidate vaccines. We describe the initial Controlled Human Infection for Vaccination Against S pyogenes (CHIVAS-M75) study, in which we aimed to identify a dose of emm75 S pyogenes that causes acute pharyngitis in at least 60% of volunteers when applied to the pharynx by swab. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• April 2021

Infant acute lymphoblastic leukemia (ALL) is characterized by a high incidence of KMT2A gene rearrangements and poor outcome. We evaluated the value of minimal residual disease (MRD) in infants with KMT2A-rearranged ALL treated within the Interfant-06 protocol, which compared lymphoid-style consolidation (protocol IB) versus myeloid-style consolidation (araC, daunorubicin, etoposide/mitoxantrone, araC, etoposide). ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

The age-standardized disability-adjusted life years rates in the Eastern Mediterranean Region are considerably higher than the global average. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

A directed approach to the differential diagnosis of acute rheumatic fever now includes the concept of low-risk versus medium-to-high risk populations ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• February 2017

Vaccines against Streptococcus pyogenes are considered as impeded vaccines because of a number of crucial barriers to development ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• June 2016

Early life rhinovirus infection influences the development of house-dust-mite induced lung disease in female, but not male mice ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• January 2016

Improved opportunities for the primary prevention of ARF now exist, because of point-of-care antigen tests for Streptococcus pyogenes, and clinical decision... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• February 2015

The prevalence of echocardiographically diagnosed RHD in adults in New Caledonia is estimated at 5.9 per 1000 ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

This review article presents the case of infant Aboriginal twins with invasive group A streptococcal infection complicated by streptococcal toxic shock... ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

This publication is a systematic analysis of all Group A Streptococcus M protein variants, to assist in the development of a vaccine. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• May 2014

This chapter describes the epidemiology, pathogenesis, clinical manifestations, diagnostic criteria, and management principles of acute rheumatic fever. ...

• Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• January 2013