T-cell lymphoblastic lymphoma (T-LBL) is a rare and aggressive lymphatic cancer, often diagnosed at a young age. Patients are treated with intensive chemotherapy, potentially followed by a hematopoietic stem cell transplantation. Although prognosis of T-LBL has improved with intensified treatment protocols, they are associated with side effects and 10-20% of patients still die from relapsed or refractory disease. Given this, the search toward less toxic anti-lymphoma therapies is ongoing. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

The long-term cardiopulmonary outcomes following preterm birth during the surfactant era remain unclear. Respiratory symptoms, particularly exertional symptoms, are common in preterm children. Therefore, cardiopulmonary exercise testing may provide insights into the pathophysiology driving exertional respiratory symptoms in those born preterm. This review aims to outline the current knowledge of cardiopulmonary exercise testing in the assessment of children born preterm in the surfactant era. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• October 2023

Using linked data, we describe changes in respiratory virus testing among children born in Western Australia in 1996-2012 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• June 2017

A lifestyle intervention starting in the first-trimester pregnancy utilising e-health mode of delivery is feasible ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• January 2020

Deborah Lea-Ann Peter Peter Ruth Lehmann Kirkham Jacoby Richmond Thornton D LK PJ PC RT AO, MBBS, MSc PhD BA (Hons) MSc MBBS MRCP(UK) FRACP PhD Honorary Emeritus Fellow Co-Head, Bacterial Respiratory Infectious Disease Group; Microbiology Lead, ...

• 1. Telethon Kids Institute
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• Past projects

Daily physical activity is critical during the early years of life for facilitating children's health and development. A large proportion of preschool children do not achieve the recommended 3 h of daily physical activity. Early childhood education and care (ECEC) services are a key setting to intervene to increase physical activity. There is a significant need for ECEC specific physical activity policy, including clearer guidelines on the amount of physical activity children should do during care, and strategies for implementation of these guidelines. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• February 2022

We investigated parental observations to identify QOL domains in children with Down Syndrome and determined whether domains differed between children and teens. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• February 2017

Reductions in pneumonia-coded hospital admissions in unvaccinated children predominated in non-Aboriginal children with low incidence of pneumonia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• October 2019

Medulloblastoma (MB) consists of four core molecular subgroups with distinct clinical features and prognoses. Treatment consists of surgery, followed by radiotherapy and cytotoxic chemotherapy. Despite this intensive approach, outcome remains dismal for patients with certain subtypes of MB, namely, MYC-amplified Group 3 and TP53-mutated SHH. Using high-throughput assays, six human MB cell lines were screened against a library of 3208 unique compounds. We identified 45 effective compounds from the screen and found that cell cycle checkpoint kinase (CHK1/2) inhibition synergistically enhanced the cytotoxic activity of clinically used chemotherapeutics cyclophosphamide, cisplatin, and gemcitabine. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

The aim of the task force was to provide technical recommendations regarding oscillometry measurement ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• February 2020

The effects of maternal alcohol-use disorder are experienced by the majority of exposed children rather than a vulnerable subgroup of this population ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020

Skin infections are an under-appreciated and dominant reason for presentation to primary healthcare centres in these indigenous communities ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019