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        Developmental-associated dysregulation of innate anti-microbial immunity in early life as a determinant of susceptibility to atopic asthma

        Pat Holt PG PhD, DSc, FRCPath, FRCPI, FAA Emeritus Honorary Researcher Patrick.Holt@telethonkids.org.au Emeritus Honorary Researcher Prof Holt established the Division of Cell Biology at the Institute's inception in 1990, with his research group's ...

        Research

        Targeting interventions to improve influenza control: a proof of principle geomapping study

        Christopher Kefyalew Hannah Blyth Alene Moore CC KA HC MBBS (Hons) DCH FRACP FRCPA PhD BSc, MPH, PhD OAM BSc (Hons) GradDipClinEpi PhD Centre Head, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases Epidemiology, ...

        Research

        The impact of monetary incentives on general fertility rates in Western Australia

        We examined general fertility rates from 1995 and 2006 by socioeconomic group, maternal age, Aboriginality and location in WA before and after the Baby Bonus. ...

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        Genetic and functional evaluation of the role of CXCR1 and CXCR2 in susceptibility to visceral leishmaniasis in north-east India

        IL8RA and IL8RB, encoded by CXCR1 and CXCR2, are receptors for interleukin (IL)-8 and other CXC chemokines involved in chemotaxis and activation of... ...

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        Unraveling the genetics of otitis media: From mouse to human and back again

        Otitis media (OM) is among the most common illnesses of early childhood, characterised by the presence of inflammation in the middle ear cavity... ...

        Research

        Pneumococcal carriage, serotype distribution, and antimicrobial susceptibility in Papua New Guinean children vaccinated with PCV10 or PCV13 in a head-to-head trial

        Children in Papua New Guinea (PNG) are at high risk of pneumococcal infections. We investigated pneumococcal carriage rates, serotype distribution, and antimicrobial susceptibility in PNG children after vaccination with 10-valent or 13-valent pneumococcal conjugate vaccines (PCV10; PCV13). ...

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        Common and Rare Genetic Variants That Could Contribute to Severe Otitis Media in an Australian Aboriginal Population

        Our goal was to identify genetic risk factors for severe otitis media (OM) in Aboriginal Australians. ...

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        Childhood Hospitalisation with Infection and Cardiovascular Disease in Early-Mid Adulthood: A Longitudinal Population-Based Study

        We investigated whether childhood infection-related hospitalisation (IRH, a marker of severity) was associated with subsequent adult CVD hospitalisation. ...

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        Folate pathway gene polymorphisms and risk of childhood brain tumors: Results from an Australian case-control study

        Recent research suggests that maternal folic acid supplementation is associated with a reduced risk of childhood brain tumors (CBT); polymorphisms in folate... ...

        Research

        Toxoplasma gondii infection is associated with mitochondrial dysfunction in-vitro

        Our results show perturbation of host mitochondrial function following T. gondii infection that likely impacts on pathogenesis of disease. ...

        Research

        Bilingualism, Parental English Skills and Child and Adolescent Development

        Francis Ha Steve Mitrou Nguyen Zubrick FG HN SR BEc PhD FASSA, FAAMHS, MSc AM PhD Program Head, Population Health, and Team Head, Human Development and Community Wellbeing Senior Research Fellow Honorary Emeritus Research Fellow 08 6319 1499 08 ...

        Research

        Impaired interferon response in plasmacytoid dendritic cells from children with persistent wheeze

        Impaired interferon response and allergic sensitization may contribute to virus-induced wheeze and asthma development in young children. Plasmacytoid dendritic cells play a key role in antiviral immunity as critical producers of type I interferons.  ...

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