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        Temporal landscape of mitochondrial proteostasis governed by the UPRmt

        Breakdown of mitochondrial proteostasis activates quality control pathways including the mitochondrial unfolded protein response (UPRmt) and PINK1/Parkin mitophagy. However, beyond the up-regulation of chaperones and proteases, we have a limited understanding of how the UPRmt remodels and restores damaged mitochondrial proteomes.  ...

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        ATFS-1 counteracts mitochondrial DNA damage by promoting repair over transcription

        The ability to balance conflicting functional demands is critical for ensuring organismal survival. The transcription and repair of the mitochondrial genome requires separate enzymatic activities that can sterically compete, suggesting a life-long trade-off between these two processes. ...

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        The mitochondrial single-stranded DNA binding protein is essential for initiation of mtDNA replication

        We report a role for the mitochondrial single-stranded DNA binding protein (mtSSB) in regulating mitochondrial DNA (mtDNA) replication initiation in mammalian mitochondria. Transcription from the light-strand promoter (LSP) is required both for gene expression and for generating the RNA primers needed for initiation of mtDNA synthesis. ...

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        Stepwise maturation of the peptidyl transferase region of human mitoribosomes

        Mitochondrial ribosomes are specialized for the synthesis of membrane proteins responsible for oxidative phosphorylation. Mammalian mitoribosomes have diverged considerably from the ancestral bacterial ribosomes and feature dramatically reduced ribosomal RNAs. The structural basis of the mammalian mitochondrial ribosome assembly is currently not well understood. Here we present eight distinct assembly intermediates of the human large mitoribosomal subunit involving seven assembly factors. ...

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        Longitudinal evidence of the impact of dog ownership and dog walking on mental health

        Emerging evidence supports the physical health and social benefits of dog ownership. This study examined the longitudinal effect of dog ownership and dog walking on mental health. ...

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        Pulmonary Gas Exchange Improves over the First Year in Preterm Infants with and without Bronchopulmonary Dysplasia

        Right shift of the peripheral oxyhaemoglobin saturation (SpO2) versus inspired oxygen pressure (PIO2) curve is a sensitive marker of pulmonary gas exchange. The aim of this study was to assess the impact of prematurity and bronchopulmonary dysplasia (BPD) on gas exchange and right-to-left shunt in the neonatal period, and its evolution over the first year of life. ...

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        OmicsVolcano: software for intuitive visualization and interactive exploration of high-throughput biological data

        Advances in omics technologies have generated exponentially larger volumes of biological data; however, their analyses and interpretation are limited to computationally proficient scientists. We created OmicsVolcano, an interactive open-source software tool to enable visualization and exploration of high-throughput biological data, while highlighting features of interest using a volcano plot interface. In contrast to existing tools, our software and user-interface design allow it to be used without requiring any programming skills to generate high-quality and presentation-ready images. ...

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        Hypoglycaemia, cardiovascular disease, and mortality in diabetes: epidemiology, pathogenesis, and management

        Study findings have suggested that hypoglycaemia is associated with an increased risk of cardiovascular events and mortality ...

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        A prospective cohort study assessing the reactogenicity of pertussis and influenza vaccines administered during pregnancy

        Data on systemic and local reactions following receipt of TIV and dTpa during pregnancy support the safety of antenatal vaccination ...

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        Reduced forced vital capacity in Aboriginal Australians: Biology or missing evidence?

        This editorial article addresses chronic obstructive pulmonary disease and lung function testing in Aboriginal Australians. ...

        Research

        Maternal vitamin D levels during pregnancy and offspring eating disorder risk in adolescence

        This is the first study to link low gestational vitamin D to increased eating disorder risk in female offspring of Caucasian mothers. ...

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        Bacillus Cereus Bacteremia and Multiple Brain Abscesses During Acute Lymphoblastic Leukemia Induction Therapy

        Bacillus cereus can cause serious infections in immunosuppressed patients. This population may be susceptible to B. cereus pneumonia, bacteremia, cellulitis,... ...

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