We discovered a previously unknown major resistance mechanism in glioma in that most EGFR domain III-targeting antibodies do not neutralize EGFRvIII ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• April 2019

Our findings present a novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

This review identifies challenges and barriers to successful development of drugs in neuro-oncology trials at the preclinical, clinical and translational stages that we believe has contributed to poor outcomes for patients over the last 30 years. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

The realisation of human potential for development requires age-specific investment throughout the 8000 days of childhood and adolescence ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• February 2017

Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• November 2013

This Australia-wide study examines whether maternal intake of folate and vitamins B6 and B12 during pregnancy is associated with development of brain tumors... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• June 2014

Interest in a possible protective effect of maternal vitamin use before or during pregnancy against childhood brain tumors (CBT) and other childhood cancers... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• November 2012

The development of Vigilant Attention (VA), the ability to focus and maintain our attention to repetitive and cognitively unchallenging tasks over time, has been investigated for more than a decade. The development of this critical executive function across the lifespan has been characterised by a rapid improvement in VA performance throughout childhood and adolescence, a steady improvement in adulthood and a slow decline in older adulthood. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

A novel mouse model for glioma demonstrating that the PI3K pathway is important for initiation of tumorigenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Emily Terrance Anya Brittany Fletcher Johns Jones Dewdney EF T AJ BD BSc (Hons) MRes PhD BSc MSc PhD BSc, MBSc, PhD Senior Research Fellow Honorary Research Associate Honorary Research Associate Postdoctoral Researcher - Oncogenic Signalling ...

• 1. Telethon Kids Institute
• Projects

These findings implicate the activation of STAT3 as one pathway that may mediate resistance to IGF-II-targeted therapy in HCC ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

We identified numerous CpGs differentially methylated in relation to gestational age at birth that appear to reflect fetal developmental processes across tissues ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• March 2020