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        61-72 of 1772 results for 'early life'

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        Nutritional approaches for the primary prevention of allergic disease: An update

        The dramatic rise in early childhood allergic diseases indicates the specific vulnerability of the immune system to early life environmental changes. ...

        Research

        Is sport an untapped resource for recovery from first episode psychosis? A narrative review and call to action

        Sport-based interventions could be an opportunity to provide intervention to individuals recovering from their first psychotic episode ...

        Research

        Airway function in infancy is linked to airflow measurements and respiratory symptoms from childhood into adulthood

        Lung airflow measurements track from birth into early adulthood, suggesting a permanent and stable airway framework is laid down in the antenatal period ...

        Research

        Immunosuppressive mechanisms of oncofetal reprogramming in the tumor microenvironment: implications in immunotherapy response

        Both fetal and tumor tissue microenvironments display immunosuppressive features characterized by the presence of specific immunomodulatory stromal and immune cell populations. Recently, we discovered shared microenvironments between hepatocellular carcinoma and fetal tissues and described this phenomenon as an oncofetal ecosystem. ...

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        Study protocol for a randomised controlled trial evaluating the effect of folic acid supplementation beyond the first trimester on maternal plasma unmetabolised folic acid in late gestation

        Taking folic acid containing supplements prior to and during early pregnancy reduces the risk of neural tube defects. Neural tube defects occur prior to 28 days postconception, after which, there is no proven benefit of continuing to take folic acid. However, many women continue to take folic acid containing supplements throughout the pregnancy. ...

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        Hospital admission for infection during early childhood influences developmental vulnerabilities at age 5 years

        This study demonstrates a pervasive effect of early life infections that require hospital admission on multiple aspects of early child development ...

        Research

        Human Milk Microbiome and Microbiome-Related Products: Potential Modulators of Infant Growth

        Infant growth trajectory may influence later-life obesity. Human milk provides a wide range of nutritional and bioactive components that are vital for infant growth. Compared to formula-fed infants, breastfed infants are less likely to develop later-onset obesity, highlighting the potential role of bioactive components present in human milk. ...

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        Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

        The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden. ...

        Research

        Histological predictors of outcome for cutaneous squamous cell carcinoma in renal transplant patients: A case-control study

        Cutaneous squamous cell carcinoma is a significant cause of morbidity for immunosuppressed patients such as organ transplant recipients; however, histological parameters which predict the likelihood of tumor progression are typically based on general population studies in which immunosuppressed patients represent only a small fraction of cases.  ...

        Research

        Early surveillance of infants and preschool children with cystic fibrosis

        Sensitive and non-invasive surveillance tools are needed for the clinical management of infants and preschool children with cystic fibrosis (CF). The lung clearance index from the multiple breath washout and functional and morphological outcomes from magnetic resonance imaging provide promising alternatives to current gold standard techniques. Early detection and treatment of lung disease during this important period offers the opportunity to improve the quality of life for individuals with CF. ...

        Research

        Adiposity associated DNA methylation signatures in adolescents are related to leptin and perinatal factors

        Epigenetics links perinatal influences with later obesity. We identifed differentially methylated CpG (dmCpG) loci measured at 17 years associated with concurrent adiposity measures and examined whether these were associated with hsCRP, adipokines, and early life environmental factors. Genome-wide DNA methylation from 1192 Raine Study participants at 17 years, identified 29 dmCpGs associated with body mass index, 10 with waist circumference and 9 with subcutaneous fat thickness. ...

        Research

        The longitudinal microbial and metabolic landscape of infant cystic fibrosis: the gut-lung axis

        In cystic fibrosis, gastrointestinal dysfunction and lower airway infection occur early and are independently associated with poorer outcomes in childhood. This study aimed to define the relationship between the microbiota at each niche during the first 2 years of life, its association with growth and airway inflammation, and explanatory features in the metabolome.  ...

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