Pulmonary function measures reflect respiratory health and are used in the diagnosis of chronic obstructive pulmonary disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• January 2011

For 20 years, the hygiene hypothesis has dominated attempts to explain the increasing prevalence of allergic disease. A causal link between maternal innate immu ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• November 2010

Pat Deborah Holt Strickland PG DH PhD, DSc, FRCPath, FRCPI, FAA PhD Emeritus Honorary Researcher Program Head, Immunobiology and Immunotherapeutic Program Patrick.Holt@telethonkids.org.au Deb.Strickland@telethonkids.org.au Emeritus Honorary ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Human Immunology

Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• August 2022

High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• July 2021

Our findings demonstrate the utility of unsupervised analysis in elucidating heterogeneity in asthma pathogenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

We aimed to investigate the risk factors for different wheezing phenotypes in Chinese young children and to explore the prognosis of recurrent wheezing ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• June 2019

Previous genome-wide association studies revealed multiple common variants involved in eczema but the role of rare variants remains to be elucidated. Here, we investigate the role of rare variants in eczema susceptibility. We meta-analyze 21 study populations including 20,016 eczema cases and 380,433 controls. Rare variants are imputed with high accuracy using large population-based reference panels. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• November 2021

These data provide proof of concept supporting the rationale for developing transplacental immune reprogramming approaches for primary disease prevention ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

Identify entrenched areas of asthma management and treatment in which progress has stalled and to challenge current principles ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018

Previous analyses of family data from the Tasmanian Longitudinal Health Study provide evidence that this phenotype has a stronger genetic cause than asthma... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

Pregnancy is a time of vulnerability for vitamin D insufficiency, and there is an emerging literature associating low levels of 25(OH)-vitamin D with... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• March 2014