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        Linking a pharmaceutical claims database with a birth defects registry to investigate birth defect rates of suspected teratogens

        Data linkage of population administrative data is being investigated as a tool for pharmacovigilance in pregnancy in Australia. ...

        Research

        Rationale for access to public sector information

        On the back of the growing capacity of networked digital information technologies to process and visualise large amounts of information in a timely, efficient a ...

        Research

        Walking the walk to include pregnant participants in non-obstetric clinical trials: Insights from the SNAP Trial

        Despite several calls for greater inclusion of pregnant people in non-obstetric clinical trials, their systematic exclusion remains common practice. Excluding pregnant individuals from clinical trials may result in unintended consequences such as inadequate treatment of medical conditions in pregnancy, inappropriate dosing of medications, and investigational therapies being used off-label outside of the context of a clinical trial, risking adverse events in the absence of demonstrated efficacy. ...

        Research

        Educational inequality across three generations in Australia

        Using a dataset of Australian children, we have the opportunity to not only investigate the transfer of educational resources across 3 generations in Australia. ...

        Research

        Potential for molecular testing for group a streptococcus to improve diagnosis and management in a high-risk population: A prospective study

        Implementation of molecular testing could improve antibiotic use in this high-burden setting ...

        Research

        HLA-DR Class II expression on myeloid and lymphoid cells in relation to HLA-DRB1 as a genetic risk factor for visceral leishmaniasis

        To understand how HLA-DR contributes to disease pathogenesis, we examined expression at the protein level in circulating myeloid and lymphoid cells of VL patients ...

        Research

        Determinants for progression from asymptomatic infection to symptomatic visceral leishmaniasis: A cohort study

        We confirmed the strong association between high DAT and/or rK39 titers and progression to disease among asymptomatic subjects ...

        Research

        Use of a primary epithelial cell screening tool to investigate phage therapy in cystic fibrosis

        This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates ...

        Research

        The importance of the exposome and allostatic load in the planetary health paradigm

        The concept of planetary health emphasizes that human health is intricately connected to the health of natural systems within the Earth's biosphere ...

        Research

        Can polymorphisms in the fatty acid desaturase (FADS) gene cluster alter the effects of fish oil supplementation on plasma and erythrocyte fatty acid profiles?

        Supplementation with fish oil may only significantly increase DHA in minor allele carriers of FADS1 SNPs ...

        Research

        Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

        Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. ...

        Research

        Previous Influenza Infection Exacerbates Allergen Specific Response and Impairs Airway Barrier Integrity in Pre-Sensitized Mice

        In this study we assessed the effects of antigen exposure in mice pre‐sensitized with allergen following viral infection on changes in lung function, cellular responses and tight junction expression. ...

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