The outcome of infants with KMT2A-germline acute lymphoblastic leukaemia (ALL) is superior to that of infants with KMT2A-rearranged ALL but has been inferior to non-infant ALL patients. Here, we describe the outcome and prognostic factors for 167 infants with KMT2A-germline ALL enrolled in the Interfant-06 study. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• January 2022

We report on the Australian experience of blinatumomab for treatment of 24 children with relapsed/refractory precursor B-cell acute lymphoblastic leukaemia (B-ALL) and high-risk genetics, resulting in a minimal residual disease (MRD) response rate of 58%, 2-year progression-free survival (PFS) of 39% and 2-year overall survival of 63%. In total, 83% (n = 20/24) proceeded to haematopoietic stem cell transplant, directly after blinatumomab (n = 12) or following additional salvage therapy (n = 8). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

A significant number of babies present transiently with low protein kinase C zeta (PKCζ) levels in cord blood T cells, associated with reduced ability to transition from a neonatal Th2 to a mature Th1 cytokine bias, leading to a higher risk of developing allergic sensitisation, compared to neonates whose T cells have 'normal' PKCζ levels. However, the importance of PKCζ signalling in regulating their differentiation from a Th2 to a Th1 cytokine phenotype propensity remains undefined. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• Jun 2023

Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• September 2021

The proposal that dietary docosahexaenoic acid (DHA) enhances neurocognitive functioning in term infants is controversial. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• November 2013

We sought to determine risk factors for the onset of bronchiectasis, using data collected by the Australian Respiratory Early Surveillance Team for Cystic... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Parents interpreted pivotal vaccine-related events in the community as requiring them to take personal responsibility for vaccine decisions ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• October 2018

Although the timeliness benchmark is being met for Indigenous Australians in palliative care, they may experience delayed initiation of care episodes ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• December 2018

These findings provide reassurance of reasonable equivalence of end-of-life outcomes for Indigenous patients who have been accepted for specialist palliative care ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• April 2020

Evidence into the role of TGF-β1 in airway epithelial repair in asthma is still controversial. This study tested the hypothesis that the reduced TGF-β1 levels previously observed in paediatric asthmatic airway epithelial cells directly contribute to the dysregulated repair seen in these cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Longer time since last acute coronary syndrome admission was associated with dispensing fewer medications types and combinations in 2008 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

This article focuses on IgE-mediated food allergies and allergic rhinitis, the most commonly seen conditions in paediatric immunology. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• October 2014