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        A Cost-Effectiveness Analysis of Sensor-Augmented Insulin Pump Therapy and Automated Insulin Suspension versus Standard Pump Therapy

        A clinical trial-based economic evaluation was performed in which the net costs and effectiveness of the two treatment modalities were calculated and... ...

        Research

        Early life arsenic exposure and acute and long-term responses to influenza A infection in mice

        Exposure to arsenic in early life has been shown to increase the rate of respiratory infections during infancy, reduce childhood lung function, and increase... ...

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        Factors influencing the assessment of lung function in mice with influenza-induced lung disease

        The constant-phase model (CPM) is commonly fit to respiratory system input impedance (Z rs) to estimate lung mechanics. ...

        Research

        Prepubertal Gynecomastia in Boys with Peutz-Jeghers Syndrome

        Peutz-Jeghers syndrome (PJS) is an autosomal-dominant disorder that arises as a consequence of mutations in the STK11 gene that encodes LKB1. ...

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        The unmet clinical needs of children with developmental coordination disorder

        The aim of this study was to understand the challenges experienced by families obtaining a diagnosis and therapy for developmental coordination disorder (DCD). Parents of 435 children aged 4-18 years with persistent motor difficulties consistent with a diagnosis of DCD completed an online survey. Diagnostic timeline and diagnostic label/s received were examined, along with therapies accessed. ...

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        Pertussis burden and acellular pertussis vaccine effectiveness in high risk children

        Pertussis hospitalisation is more common among infants born prematurely, who have significant comorbidities, or are Indigenous, but acellular pertussis (aP) vaccine effectiveness (VE) estimates in these sub-groups are lacking. We measured aP VE by Indigenous status, and policy-relevant categories of prematurity and comorbidity, in a population-based Australian cohort. ...

        Research

        Data linkage in an established longitudinal cohort: The Western Australian Pregnancy Cohort (Raine) Study

        A healthy diet was consistently associated with higher academic performance ...

        Research

        The impact of pandemic A(H1N1)pdm09 influenza and vaccine-associated adverse events on parental attitudes and influenza vaccine uptake in young children

        This paper reports on the shift in parental attitude to vaccination after 2010, due to an unprecedented increase in febrile reactions in children receiving... ...

        Research

        Targeting interventions to improve influenza control: a proof of principle geomapping study

        Christopher Kefyalew Hannah Blyth Alene Moore CC KA HC MBBS (Hons) DCH FRACP FRCPA PhD BSc, MPH, PhD OAM BSc (Hons) GradDipClinEpi PhD Centre Head, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases Epidemiology, ...

        Research

        Normative data for multiple breath washout outcomes in school-aged Caucasian children

        The multiple breath nitrogen washout (N2MBW) technique is increasingly used to assess the degree of ventilation inhomogeneity in school-aged children with lung disease. However, reference values for healthy children are currently not available. ...

        Research

        B Part of It School Leaver Study: A Repeat Cross-Sectional Study to Assess the Impact of Increasing Coverage With Meningococcal B (4CMenB) Vaccine on Carriage of Neisseria meningitidis

        Recombinant protein-based vaccines targeting serogroup B meningococci protect against invasive disease but impacts on carriage are uncertain. This study assessed carriage prevalence of disease-associated meningococci in 2018-2020 as the proportion of vaccinated adolescents increased following introduction of a school-based 4CMenB immunization program. ...

        Research

        Modeling COVID-19 disease processes by remote elicitation of causal Bayesian networks from medical experts

        COVID-19 is a new multi-organ disease causing considerable worldwide morbidity and mortality. While many recognized pathophysiological mechanisms are involved, their exact causal relationships remain opaque. Better understanding is needed for predicting their progression, targeting therapeutic approaches, and improving patient outcomes. While many mathematical causal models describe COVID-19 epidemiology, none have described its pathophysiology. ...

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