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        733-744 of 1501 results for 'clinical trials'

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        Understanding the relative contributions of the lung, respiratory muscles and the blood vessels to severity of chronic lung disease in very preterm infants (PIFCO Follow-up)

        Graham Ingrid Shannon Hall Laing Simpson GL IL SS BAppSci PhD CRFS FANZSRS FThorSoc FERS BSc PhD BMedSci (hons), PhD Honorary Research Associate Head, Children's Respiratory Science Co-Head, Children's Lung Health; Senior Research Fellow 6319 1828 ...

        Research

        Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease

        We observed an association between Type III DNA methyltransferase presence and Otitis Media-associated middle ear isolates ...

        Research

        Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

        Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. ...

        Research

        Clinical experience with SUBA-itraconazole at a tertiary paediatric hospital

        Itraconazole remains a first-line antifungal agent for certain fungal infections in children, including allergic bronchopulmonary aspergillosis (ABPA) and sporotrichosis, but poor attainment of therapeutic drug levels is frequently observed with available oral formulations. A formulation of 'SUper BioAvailability itraconazole' (SUBA-itraconazole; Lozanoc®) has been developed, with adult studies demonstrating rapid and reliable attainment of therapeutic levels, yet paediatric data are lacking. ...

        Research

        High Nasopharyngeal Carriage of Non-Vaccine Serotypes in Western Australian Aboriginal People Following 10 Years of Pneumococcal Conjugate Vaccination

        Invasive pneumococcal disease (IPD) continues to occur at high rates among Australian Aboriginal people. ...

        Research

        A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in children

        Acute lower respiratory infections (ALRI) are a major cause of hospitalisation in young children ...

        Research

        Linkage of the Australian Childhood Immunisation Register (ACIR) and state-based registers to evaluate and inform Australia’s immunisation program

        Christopher Hannah Tom Blyth Moore Snelling CC HC T MBBS (Hons) DCH FRACP FRCPA PhD OAM BSc (Hons) GradDipClinEpi PhD BMBS DTMH GDipClinEpid PhD FRACP Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases ...

        Research

        Ear Portal: An ENT and Audiology referral portal for improving access to ear health services for children using telehealth

        Chris Deborah Peter Tanisha Greta Karina Brennan-Jones Lehmann Richmond Cayley Bernabei Tao C D PC TC GB KT PhD AO, MBBS, MSc MBBS MRCP(UK) FRACP BBiomed (Hons) BSc B.SpLPath&Aud, MClincAud, PhD Head, Ear Health Honorary Emeritus Fellow Head, ...

        Research

        Duration of protection after first dose of acellular pertussis vaccine in infants

        Without a booster dose, the effectiveness of 3 doses waned more rapidly from 2 to 4 years of age than previously documented for children >6 years of age who... ...

        Research

        Characterization of a G1P[8] rotavirus causing an outbreak of gastroenteritis in the Northern Territory, Australia, in the vaccine era

        In 2010, a large outbreak of rotavirus gastroenteritis occurred in the Alice Springs region of the Northern Territory, Australia. ...

        Research

        Validating the Communication and Symbolic Behavior Scales–Developmental Profile Infant–Toddler Checklist (CSBS–DP ITC) Beyond Infancy in the CDKL5 Deficiency Disorder

        CDKL5 deficiency disorder (CDD) results in early-onset epilepsy and lifelong cognitive and motor impairments. With no validated measure for communication in CDD, this study evaluated the psychometric properties of the Communication and Symbolic Behavior Scales-Developmental Profile Infant Toddler Checklist. ...

        Research

        A role for early oral exposure to house dust mite allergens through breast milk in IgE-mediated food allergy susceptibility

        This study highlights an unpredicted potential risk factor for the development of food allergy, that is, D pteronyssinus allergens in breast milk ...

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