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        Understanding the relative contributions of the lung, respiratory muscles and the blood vessels to severity of chronic lung disease in very preterm infants (PIFCO Follow-up)

        Graham Ingrid Shannon Hall Laing Simpson GL IL SS BAppSci PhD CRFS FANZSRS FThorSoc FERS BSc PhD BMedSci (hons), PhD Honorary Research Associate Head, Children's Respiratory Science Co-Head, Children's Lung Health; Senior Research Fellow 6319 1828 ...

        Research

        Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease

        We observed an association between Type III DNA methyltransferase presence and Otitis Media-associated middle ear isolates ...

        Research

        Ancestral SARS-CoV-2, but not Omicron, replicates less efficiently in primary pediatric nasal epithelial cells

        Children typically experience more mild symptoms of Coronavirus Disease 2019 (COVID-19) when compared to adults. There is a strong body of evidence that children are also less susceptible to Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection with the ancestral viral isolate. ...

        Research

        AGAR Kids

        Christopher Anita Blyth Williams CC AW MBBS (Hons) DCH FRACP FRCPA PhD MInfecDis MPhil(App Epi) Director, Wesfarmers Centre of Vaccines and Infectious Diseases; Co-Head, Infectious Diseases Epidemiology, Wesfarmers Centre of Vaccines and Infectious ...

        Research

        Causes and Clinical Features of Childhood Encephalitis: A Multicenter, Prospective Cohort Study

        Epidemic viral infections predominated as causes of childhood encephalitis in Australia. The leading causes include vaccine-preventable diseases ...

        Research

        In utero and postnatal vitamin D exposure and allergy risk

        This review article examines the evidence of the impact of in utero and postnatal vitamin D exposure on allergy risk in childhood ...

        Research

        Predominance of nontypeable haemophilus influenzae in children with otitis media

        In Australia the 7-valent pneumococcal conjugate vaccine (PCV7) is administered at 2, 4 and 6 months of age, with no booster dose. ...

        Research

        Does mum know best? Should we be vaccinating mothers to protect their babies from ear and lung disease?

        Elke Lea-Ann Ruth Peter Seppanen Kirkham Thornton Richmond ES LK RT PC BSc PhD PhD PhD MBBS MRCP(UK) FRACP Program Manager, Bacterial Respiratory Infectious Disease Group Co-Head, Bacterial Respiratory Infectious Disease Group; Microbiology Lead, ...

        Research

        An infant mouse model of influenza-driven nontypeable Haemophilus influenzae colonization and acute otitis media suitable for preclinical testing of novel therapies

        Nontypeable Haemophilus influenzae (NTHi) is a major otitis media (OM) pathogen, with colonization a prerequisite for disease development. Most acute OM is in children <5 years old, with recurrent and chronic OM impacting hearing and learning. Therapies to prevent NTHi colonization and/or disease are needed, especially for young children. Respiratory viruses are implicated in driving the development of bacterial OM in children. ...

        Research

        Evidence of maternal transfer of antigen-specific antibodies in serum and breast milk to infants at high-risk of S. pneumoniae and H. influenzae disease

        Children in low-mid income countries, and First Nations children in high-income countries, experience disproportionately high rates of Streptococcus pneumoniae and Haemophilus influenzae infections and diseases including pneumonia and otitis media. ...

        Research

        High Nasopharyngeal Carriage of Non-Vaccine Serotypes in Western Australian Aboriginal People Following 10 Years of Pneumococcal Conjugate Vaccination

        Invasive pneumococcal disease (IPD) continues to occur at high rates among Australian Aboriginal people. ...

        Research

        A retrospective population-based cohort study identifying target areas for prevention of acute lower respiratory infections in children

        Acute lower respiratory infections (ALRI) are a major cause of hospitalisation in young children ...

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