Australian First Nations children are at very high risk of early, recurrent, and persistent bacterial otitis media and respiratory tract infection. With the PREVIX randomised controlled trials, we aimed to evaluate the immunogenicity of novel pneumococcal conjugate vaccine (PCV) schedules. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

B lymphopoiesis is characterized by progressive loss of multipotent potential in hematopoi-etic stem cells, followed by commitment to differentiate into B cells, which mediate the humoral response of the adaptive immune system. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• May 2022

Acute rheumatic fever (ARF) is an abnormal immune reaction following Streptococcus pyogenes (Strep A) infection of the throat, and likely the skin. Primary prevention is the prompt and appropriate antibiotic treatment of Strep A infection, and it can reduce the risk of developing ARF and subsequent rheumatic heart disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• May 2021

In recent decades, the conduct of uniform prospective clinical trials has led to improved remission rates and survival for patients with acute myeloid leukaemia and acute lymphoblastic leukaemia. However, high-risk patients continue to have inferior outcomes, where chemoresistance and relapse are common due to the survival mechanisms utilised by leukaemic cells. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• June 2021

Trans youth are at high risk of mental health difficulties and negative life events. Strong parental support is highly protective however there is little understanding of what factors facilitate the process of parental understanding and acceptance of a child’s gender identity. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

There was a significant improvement in the management of anaphylaxis after the introduction of intensified physician training programs ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• September 2018

Early intensification with postinduction myeloid-type chemotherapy courses did not significantly improve outcome for infant acute lymphoblastic leukemia ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• September 2019

This study suggests that low Apgar score is associated with higher risk of autism spectrum disorder, and in particular autistic disorder ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Vanessa Timo Fear Lassmann VF T BSc (Hons), PhD BSc (Hons) MSc PhD Head, Translational Genetics Team Feilman Fellow; Program Head, Precision Health and Team Lead, Computational Biology 08 6319 1022 vanessa.fear@telethonkids.org.au timo.lassmann@ ...

• 1. Telethon Kids Institute
• Projects

Viruses, bacteria, and parasites have developed strategies to invade and establish long-term infections in their hosts. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015

Uniformly low expression of IFN and IFNGR1 in PKDL skin biopsies could explain parasite persistence ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• December 2014

This editorial article addresses chronic obstructive pulmonary disease and lung function testing in Aboriginal Australians. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• January 2015