Neutrophil elastase is a significant risk factor for structural lung disease in cystic fibrosis, and Pseudomonas aeruginosa airway infection is linked with neutrophilic inflammation and substantial respiratory morbidity. We aimed to evaluate how neutrophil elastase (NE) activity changes after P. aeruginosa eradication and influences early disease outcomes. We assessed participants in the AREST CF cohort between 2000 and 2018 who had P. aeruginosa cultured from their routine annual bronchoalveolar lavage (BAL) fluid and who underwent eradication treatment and a post eradication BAL. Factors associated with persistent P. aeruginosa infection, persistent neutrophilic inflammation following eradication and worse structural lung disease one year post-eradication were evaluated. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Our data associates IL-1α with early structural lung damage in CF and suggests this pathway as a novel anti-inflammatory target ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018

There is controversy regarding whether cystic fibrosis (CF) airway epithelial cells (AECs) are intrinsically proinflammatory. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• February 2011

This study investigated the nature and prevalence of atypical pain responses in Rett syndrome and their relationships with specific MECP2 mutations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2010
• May 2010

Amidst the evolving COVID-19 pandemic, understanding the transmission dynamics of the SARS-CoV-2 virus is key to providing peace of mind for the community and informing policy-making decisions. While available data suggest that school-aged children are not significant spreaders of SARS-CoV-2, the possibility of transmission in schools remains an ongoing concern, especially among an aging teaching workforce. Even in low-prevalence settings, communities must balance the potential risk of transmission with the need for students' ongoing education. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• February 2021

This study calls for the early identification of children who are vulnerable to maltreatment, the better identification of the duration and severity of maltreatment experiences, and the provision of continued care and support, to reduce the child's deliberate self harm risk in adolescence. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• May 2017

In this study, the Australian Early Development Census scores of 19,203 children were linked to information on child maltreatment allegations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• February 2018

The risk of repetition of deliberate self-harm peaks in the first 7 days after a deliberate self-harm episode. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• February 2016

Pulmonary exacerbations in cystic fibrosis are characterized by airway inflammation and may cause irreversible lung damage. Early identification of such exacerbations may facilitate early initiation of treatment, thereby potentially reducing long-term morbidity. Research question: Is it possible to predict pulmonary exacerbations in children with cystic fibrosis, using inflammatory markers obtained from BAL fluid? ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• December 2020

The SA MenB vaccine carriage study aims to assess the impact of 4CMenB on carriage of N. meningitidis in adolescents ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• July 2018

The Future Proofing Study (FPS) was established to examine factors associated with the onset and course of mental health conditions during adolescence. This paper describes the design, methods, and baseline characteristics of the FPS cohort. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• November 2022

Ewan Mark Punam Susan Tasmin Cameron Connell Amratia Rumisha Symons EC MC PA SR TS BSc PhD MSc PhD PhD (Biostatistics) Director of Malaria Risk Stratification Research Assistant, Epidemiology Statistics Honorary Research Associate Honorary Research ...

• 1. Telethon Kids Institute
• Projects