One third of children require repeat ventilation tube insertion (VTI) for otitis media. Disease recurrence is associated with persistent middle ear bacterial biofilms. With demonstration that Dornase alfa (a DNase) disrupts middle ear effusion biofilms ex vivo, we identified potential for this as an anti-biofilm therapy to prevent repeat VTI. First, safety and tolerability needed to be measured. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• December 2023

Children with ADHD are disadvantaged from an early age in key areas of learning, and this risk increased with reduction in gestational age at birth ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• July 2020

From 1990 to 2005, there was an increase in prevalence of parents with a prior history of mental health disorders in WA. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• May 2013

Describe the epidemiology of Staphylococcus aureus bacteremia in children and adolescents younger than 18 years from Australia and New Zealand ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Marked increases in maternal age and primiparous births were observed. A four-fold increase in the rates of pre-existing medical complications over time... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• August 2013

Sarra Timo Christopher Lea-Ann Ruth Deborah Jamieson Lassmann Blyth Kirkham Thornton Lehmann SE T CC LK RT D BSc (Hons) MSc PhD BSc (Hons) MSc PhD MBBS (Hons) DCH FRACP FRCPA PhD PhD PhD AO, MBBS, MSc Senior Research Fellow Feilman Fellow; Program ...

• 1. Telethon Kids Institute
• Our research
• Past teams
• Genetics and Health

The aim was to document the aetiology of acute lower respiratory infection (ALRI) hospitalisations in Western Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

Given the beneficial effect of infant rotavirus vaccination efforts should be taken to optimize rotavirus vaccine coverage in those at highest risk ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• February 2019

Respiratory viruses, particularly respiratory syncytial virus and human metapneumovirus, are major contributors to pneumonia in Australian children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2019
• March 2019

Melissa Fiona Helen Rebecca Peter O'Donnell Stanley Leonard Glauert Jacoby M FJ HM RA PJ BPsych (Hons), MPsych, GradDip Ed, PhD FAA FASSA MSc MD FFPHM FAFPHM FRACP FRANZCOG HonDSc HonDUniv HonFRACGP HonMD HonFRCPCH HonLLB (honoris causa) MBChB MPH ...

• 1. Telethon Kids Institute
• Projects

Pneumonia remains a leading cause of hospitalization and death among young children worldwide, and the diagnostic challenge of differentiating bacterial from non-bacterial pneumonia is the main driver of antibiotic use for treating pneumonia in children. Causal Bayesian networks (BNs) serve as powerful tools for this problem as they provide clear maps of probabilistic relationships between variables and produce results in an explainable way by incorporating both domain expert knowledge and numerical data. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• March 2023

Language is one of the most remarkable developmental accomplishments of early childhood. Language connects us with others and is an essential tool for literacy, education, employment and lifelong learning. ...

• 1. Telethon Kids Institute
• Our research
• Research Topics