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        817-828 of 1460 results for 'risk factors'

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        A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies

        These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data ...

        Research

        Egg-sensitised infants have elevated CD4+ effector memory T regulatory cells from birth

        IgE-mediated sensitisation to egg is common in infants. In some cases, the processes leading to egg sensitisation are established in early life, even before introduction to solid foods. The underlying mechanisms remain poorly understood.  ...

        Research

        Pre-and Postnatal Vitamin D Status and Allergy Outcomes in Early Childhood

        The dramatic increase in the prevalence of allergic disease in recent decades reflects environmental and behavioural changes that have altered patterns of early immune development. The very early onset of allergic diseases points to the specific vulnerability of the developing immune system to environmental changes and the development of primary intervention strategies is crucial to address this unparalleled burden. ...

        Research

        ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma

        COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

        Research

        Parental Challenges, Facilitators and Needs Associated with Supporting and Accepting Their Trans Child’s Gender

        Parental support is strongly correlated with protective factors for trans youth yet most experience parental rejection or ambivalence regarding their gender. Many parents report a desire to support their child but indicate lack of understanding and support as key barriers. We aimed to develop a nuanced understanding of the challenges and facilitators experienced by Australian parents in developing understanding, support and acceptance of their child’s gender and their needs to do so. ...

        Research

        Knowledge is Power: Trans Young People’s Perceptions of Parental Reactions to Their Gender Identity, and Perceived Barriers and Facilitators to Parental Support

        Parental support is strongly correlated with protective factors for trans youth, however, most experience unsupportive parental attitudes. We aimed to better understand how youth perceive parental reactions to their gender identity disclosure and what they consider to be barriers to, and facilitators of, support. ...

        Research

        Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: A prospective cohort study

        This longitudinal, prospective study investigated the association between maternal vitamin D status and peak bone mass of offspring in 341 mother and... ...

        Research

        Physical and mental health in mothers of children with Down syndrome.

        Physical and mental health in mothers of children with Down syndrome. ...

        Research

        Survival of children and adolescents with intellectual disability following gastrostomy insertion

        Whilst gastrostomy insertion was associated with lower survival rates than children without gastrostomy, survival improved with time ...

        Research

        END RHD Community Project - Kimberley (Rheumatic Fever Strategy)

        Dylan John Jonathan Rosemary Barth Jacky Carapetis AM Wyber DB JJ JR R B.Tech, MPH, PhD AM MBBS FRACP FAFPHM PhD FAHMS MBChB MPH FRACGP PhD Postdoctoral Research Fellow / Epidemiologist Community Researcher Executive Director; Head, Strep A ...

        Research

        Comparison of neonatal T regulatory cell function in Papua New Guinean and Australian newborns

        We compared neonatal T reg from children born in western conditions (Australia) with those of neonates born in high microbial conditions (Papua New Guinea)... ...

        Research

        Cultures of HRV-C for investigations of pathogenesis in children

        Anthony Belinda Ingrid Kicic Hales Laing A BJ IL BSc (Hons) PhD BSc (Hons) PhD BSc PhD Rothwell Family Fellow; Head, Airway Epithelial Research Senior Manager, Research Platforms Head, Children's Respiratory Science 6319 1828 Anthony.Kicic@ ...

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