Browse study websites

Discover. Prevent. Cure.

Menu Fundraise Donate

    Recommended pages

      Do you mean

        73-84 of 115 results for 'Professor Stephen Stick'

        Refine research

        Research

        Use of a primary epithelial cell screening tool to investigate phage therapy in cystic fibrosis

        This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates ...

        Research

        Suppression of adrenomedullin contributes to vascular leakage and altered epithelial repair during asthma

        The anti-inflammatory peptide, adrenomedullin (AM), and its cognate receptor are expressed in lung tissue, but its pathophysiological significance in airway... ...

        Research

        The airway epithelium is a direct source of matrix degrading enzymes in bronchiolitis obliterans syndrome

        Long-term survival after lung transplantation is hindered by the development of bronchiolitis obliterans syndrome (BOS). ...

        Research

        ACE2 expression is elevated in airway epithelial cells from older and male healthy individuals but reduced in asthma

        COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

        Research

        Accumulation mode particles and LPS exposure induce TLR-4 dependent and independent inflammatory responses in the lung

        We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

        Research

        Conditionally reprogrammed primary airway epithelial cells maintain morphology, lineage and disease specific functional characteristics

        Here, we show that conditionally reprogrammed airway epithelial cells (CRAECs) can be established from both healthy and diseased phenotypes. ...

        Research

        The genetic and epigenetic landscapes of the epithelium in asthma

        Genetic factors in airway epithelial cells that are functionally associated with asthma pathogenesis ...

        Research

        Productive infection of human embryonic stem cell-derived nkx2.1+ respiratory progenitors with human rhinovirus.

        Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions. ...

        Research

        Transcription factor p63 regulates key genes and wound repair in human airway epithelial Basal cells

        The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

        Research

        Genome Sequence of a Lytic Staphylococcus aureus Bacteriophage Isolated from Breast Milk

        We identified a double-stranded DNA (dsDNA) bacteriophage appearing to belong to Herelleviridae, genus Kayvirus. The bacteriophage, Biyabeda-mokiny 1, was isolated from breast milk using a clinical isolate of Staphylococcus aureus. ...

        Research

        Visualisation of Multiple Tight Junctional Complexes in Human Airway Epithelial Cells

        Apically located tight junctions in airway epithelium perform a fundamental role in controlling macromolecule migration through paracellular spaces. ...

        Research

        Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis

        Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. ...

        Page 7 of 10