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        73-84 of 151 results for 'animal research'

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        Early aberrant antibody responses of aeroallergen sensitised people to subclinical bacterial infection

        Early aberrant antibody responses, aeroallergen sensitised people, subclinical bacterial infection ...

        Research

        Biodiesel exhaust: The need for a systematic approach to health effects research

        Biodiesel is a generic term for fuel that can be made from virtually any plant or animal oil via transesterification of triglycerides with an alcohol... ...

        Research

        T-cell responses against rhinovirus species A and C in asthmatic and healthy children

        Infections by RV species A and C are the most common causes of exacerbations of asthma and a major cause of exacerbations of other respiratory disease. ...

        Research

        Immunodominant T-cell epitopes in the VP1 capsid protein of rhinovirus species A and C

        Our results indicate a dissociation between the antibody and T-cell responses to rhinoviruses ...

        Research

        Bacterial and Fungal Gut Community Dynamics Over the First 5 Years of Life in Predominantly Rural Communities in Ghana

        Bacterial and fungal microbiotas are increasingly recognized as important in health and disease starting early in life. However, microbiota composition has not yet been investigated in most rural, low-resource settings, and in such settings, bacterial and fungal microbiotas have not been compared. ...

        Research

        Ontogeny of plasma cytokine and chemokine concentrations across the first week of human life

        Early life is marked by distinct and rapidly evolving immunity and increased susceptibility to infection. The vulnerability of the newborn reflects development of a complex immune system in the face of rapidly changing demands during the transition to extra-uterine life. ...

        Research

        Developmental vitamin D deficiency increases foetal exposure to testosterone

        Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders which are more common in males. The 'prenatal sex steroid' hypothesis links excessive sex-steroid exposure during foetal life with the behavioural differences observed in ASD. However, the reason why sex steroid exposure may be excessive remains unclear. Epidemiological studies have identified several environmental risk factors associated with ASD, including developmental vitamin D (DVD) deficiency. ...

        Research

        Comparison of rhinovirus antibody titers in children with asthma exacerbations and species-specific rhinovirus infection

        Asthma exacerbations are associated with human rhinovirus (HRV) infections, and more severe exacerbations are associated with HRV-C. ...

        Research

        Antibacterial antibody responses associated with the development of asthma in house dust mite-sensitised and non-sensitised children

        We aimed to measure the antibody development to 2 bacteria in a birth cohort at high risk of allergic disease, and to assess which responses are asthma-linked. ...

        Research

        IRF7-Associated Immunophenotypes Have Dichotomous Responses to Virus/Allergen Coexposure and OM-85-Induced Reprogramming

        High risk for virus-induced asthma exacerbations in children is associated with an IRF7lo immunophenotype, but the underlying mechanisms are unclear. Here, we applied a Systems Biology approach to an animal model comprising rat strains manifesting high versus low susceptibility to experimental asthma, induced by virus/allergen coexposure, to elucidate the mechanism(s)-of-action of the high-risk asthma immunophenotype. ...

        Research

        Opportunities to strengthen respiratory virus surveillance systems in Australia: lessons learned from the COVID-19 response

        Disease surveillance data was critical in supporting public health decisions throughout the coronavirus disease 2019 (COVID-19) pandemic. At the same time, the unprecedented circumstances of the pandemic revealed many shortcomings of surveillance systems for viral respiratory pathogens. Strengthening of surveillance systems was identified as a priority for the recently established Australian Centre for Disease Control, which represents a critical opportunity to review pre-pandemic and pandemic surveillance practices, and to decide on future priorities, during both pandemic and inter-pandemic periods. ...

        Research

        Effects of Ser47-Point Mutation on Conformation Structure and Allergenicity of the Allergen of Der p 2, a Major House Dust Mite Allergen

        The mutant Der p 2 had altered structure and reduced ability to stimulate pro-inflammatory responses and to bind IgE ...

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