Whereas asthma was rare in the late 1800s and early 1900s, the marked increase in its incidence and prevalence since the 1960s points to substantial gene ×... ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2014
• September 2014

The objective of this study was to examine the influence of viral respiratory infection (VRI) on treatment response in acute asthma in children. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2012
• January 2012

This study investigated the potential role of ST2 in children with acute asthma. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2009
• March 2009

Lung transcriptomics studies in asthma have provided valuable information in the whole lung context, however, deciphering the individual contributions of the airway and parenchyma in disease pathogenesis may expedite the development of novel targeted treatment strategies. In this study, we performed transcriptomics on the airway and parenchyma using a house dust mite (HDM)-induced model of experimental asthma that replicates key features of the human disease. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2023
• January 2023

Despite advances in asthma therapeutics, the burden remains highest in preschool children; therefore, it is critical to identify primary care tools that distinguish preschool children at high risk for burdensome disease for further evaluation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• October 2022

Research question: Are asthma and allergies more common in adolescents conceived with assisted reproductive technologies (ART) compared with adolescents conceived without? ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• July 2022

In asthma, a significant portion of the interaction between genetics and environment occurs through microbiota. The proposed mechanisms behind this interaction are complex and at times contradictory. This review covers recent developments in our understanding of this interaction: the "microbial hypothesis" and the "farm effect"; the role of endotoxin and genetic variation in pattern recognition systems; the interaction with allergen exposure; the additional involvement of host gut and airway microbiota; the role of viral respiratory infections in interaction with the 17q21 and CDHR3 genetic loci; and the importance of in utero and early-life timing of exposures. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• March 2021

Human Respiratory Syncytial Virus and Human Rhinovirus are the most frequent cause of respiratory tract infections in infants and children and are major triggers of acute viral bronchiolitis, wheezing and asthma exacerbations. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• September 2020

These findings suggest that genetic variants at the VDR locus may play a role in acute wheeze/asthma severity in children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2020
• May 2020

The aim of this study was to longitudinally assess the prevalence of allergic sensitization, asthma, eczema and hay fever from infancy to adulthood ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• August 2018

While spirometry contributes to asthma diagnosis and management in older children, it has a limited role in younger children whom are unable to perform FOM. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• December 2017

Our findings suggest that the proportion of degranulated basophils can also be associated with recurrent exacerbations ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• November 2018