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        ‘Torn in two’: Experiences of Mothers Who Are Pregnant when Their Child Is Diagnosed With Cancer

        Mothers of children diagnosed with cancer have been shown to experience high rates of psychological distress and poor physical health. Pregnancy further increases the healthcare needs of mothers due to the marked physiological changes and psychological adaptations. ...

        Research

        Safety, tolerability, and immunogenicity of V114 pneumococcal vaccine compared with PCV13 in a 2+1 regimen in healthy infants: A phase III study (PNEU-PED-EU-2)

        This phase III study evaluated safety, tolerability, and immunogenicity of V114 (15-valent pneumococcal conjugate vaccine) in healthy infants. V114 contains all 13 serotypes in PCV13 and additional serotypes 22F and 33F. ...

        Research

        Biofilm forming potential and antimicrobial susceptibility of newly emerged Western Australian Bordetella pertussis clinical isolates

        Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomic analysis revealed significant differences in protein expression in B. pertussis biofilms ...

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        Public-private collaboration in clinical research during pregnancy, lactation, and childhood

        This position statement summarises a view of academia regarding standards for clinical research in collaboration with commercial enterprises, focussing on... ...

        Research

        Pediatric meningioma: Current approaches and future direction

        With improvement in leukemia therapy, central nervous system (CNS) tumors are the leading cause of cancer mortality in children and the most expensive... ...

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        Rare childhood cancers—an increasing entity requiring the need for global consensus and collaboration

        Rare childhood cancers have not benefited to the same extent from the gains that have been made for their frequently occurring counterparts. ...

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        Irreversible growth plate fusions in children with medulloblastoma treated with a targeted hedgehog pathway inhibitor

        We report on 3 children treated with vismodegib who developed widespread growth plate fusions that persist long after cessation of therapy. ...

        Research

        Medulloblastoma Down Under 2013: a report from the third annual meeting of the International Medulloblastoma Working Group

        Medulloblastoma is curable in approximately 70 % of patients. Over the past decade, progress in improving survival using conventional therapies has stalled... ...

        Research

        Toll-like receptor 2 ligands inhibit Th2 responses to mite allergen

        There is intense interest in the interaction between microbial compounds and allergy. ...

        Research

        A Phase 3 Randomized, Double-blind, Placebo-controlled Study to Evaluate the Safety and Efficacy of MEDI8897, a Monoclonal Antibody With an Extended Half-life Against Respiratory Syncytial Virus, in Healthy Late Preterm and Term Infants (MELODY)

        Jennifer Peter Kent Richmond J PC RN MBBS MRCP(UK) FRACP Clinical Research Manager Head, Vaccine Trials Group Jennifer.Kent@telethonkids.org.au Clinical Research Manager Head, Vaccine Trials Group Jennifer completed her Diploma of Nursing in 1986 at ...

        Research

        PATZ1 fusions define a novel molecularly distinct neuroepithelial tumor entity with a broad histological spectrum

        Large-scale molecular profiling studies in recent years have shown that central nervous system (CNS) tumors display a much greater heterogeneity in terms of molecularly distinct entities, cellular origins and genetic drivers than anticipated from histological assessment. ...

        Research

        Incidence and survival for childhood central nervous system tumours in Australia, 1983–2016

        To investigate incidence and survival of childhood tumours of the central nervous system (CNS) by histological subtype, tumour behaviour and tumour grade. Methods: National, population-based data on all children under 15 years old diagnosed with a CNS tumour between 1983 and 2016 were sourced from the Australian Childhood Cancer Registry. Incidence rate trends were calculated using Joinpoint regression. ...

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