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        73-84 of 154 results for 'governance'

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        Impact of ventilation tube insertion on long-term language outcomes at 6 and 10 years of age: A prospective pregnancy cohort study

        Investigating the impact of early childhood ventilation tube insertion (VTI) on long-term language outcomes.  ...

        Research

        Murine bone-derived mesenchymal stem cells undergo molecular changes after a single passage in culture

        The rarity of the mesenchymal stem cell (MSC) population poses a significant challenge for MSC research. Therefore, these cells are often expanded in vitro, prior to use. However, long-term culture has been shown to alter primary MSC properties. ...

        Research

        Characterization of mesenchymal stem cells in pre-B acute lymphoblastic leukemia

        Components of the bone marrow microenvironment (BMM) have been shown to mediate the way in which leukemia develops, progresses and responds to treatment. Increasing evidence shows that leukemic cells hijack the BMM, altering its functioning and establishing leukemia-supportive interactions with stromal and immune cells. ...

        Research

        RUNX2 regulates leukemic cell metabolism and chemotaxis in high-risk T cell acute lymphoblastic leukemia

        T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignancy with inferior outcome compared with that of B cell ALL. Here, we show that Runt-related transcription factor 2 (RUNX2) was upregulated in high-risk T-ALL with KMT2A rearrangements (KMT2A-R) or an immature immunophenotype. In KMT2A-R cells, we identified RUNX2 as a direct target of the KMT2A chimeras, where it reciprocally bound the KMT2A promoter, establishing a regulatory feed-forward mechanism. ...

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        Topical versus systemic antibiotics for chronic suppurative otitis media

        To assess the relative effectiveness of topical versus systemic antibiotics for people with chronic suppurative otitis media ...

        Research

        Global supermarkets' corporate social responsibility commitments to public health: A content analysis

        Investigate the world's largest and most powerful supermarkets' publically available CSR commitments to determine their potential impact on public health ...

        Research

        CFC Report

        Download Investigators: Cate Taylor, Daniel Christensen Partners: Tasmanian Early Years Foundation The Tasmanian Government has made a significant commitment in recent years to ensure children have the best possible start in life. However, the cycle ...

        Research

        Recurrent otitis media and behaviour problems in middle childhood: A longitudinal cohort study

        To investigate the long-term effects of early-life recurrent otitis media (OM) and subsequent behavioural problems in children at the age of 10 years. ...

        Research

        Population Wide Monitoring of Child Health and Development in Tuvalu

        Alanna Sincovich AS BPsych(Hons), PhD Senior Research Officer 08 6375 6108 Alanna.sincovich@telethonkids.org.au Senior Research Officer @AlannaSincovich Alanna is a Senior Research Officer at the Telethon Kids Institute. Her research takes a ...

        Research

        Exploiting the reactive oxygen species imbalance in high-risk paediatric acute lymphoblastic leukaemia through auranofin

        The prognosis for high-risk childhood acute leukaemias remains dismal and established treatment protocols often cause long-term side effects in survivors. This study aims to identify more effective and safer therapeutics for these patients. ...

        Research

        Do parent-reported early indicators predict later developmental language disorder? A Raine Study investigation

        Developmental language disorder (DLD) is one of the most common neurodevelopmental conditions. Due to variable rates of language growth in children under 5 years, the early identification of children with DLD is challenging. Early indicators are often outlined by speech pathology regulatory bodies and other developmental services as evidence to empower caregivers in the early identification of DLD. ...

        Research

        Supporting the Social-Emotional Well-Being of Elementary School Students Who Are Deaf and Hard of Hearing: A Pilot Study

        Children who are Deaf and Hard of Hearing, their parents, Teachers of the Deaf, and other community stakeholders were involved in co-designing a web-based resource to support students' social-emotional well-being. ...

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