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        Overall efficacy of HPV-16/18 AS04-adjuvanted vaccine against grade 3 or greater cervical intraepithelial neoplasia

        We report vaccine efficacy against CIN3+ and adenocarcinoma in situ (AIS) in the end-of-study analysis of PApilloma TRIal against Cancer In young Adults. ...

        Research

        Method of bacterial killing differentially affects the human innate immune response to Staphylococcus epidermidis

        In vitro investigations of human innate immune responses to extracellular bacteria commonly utilise killed preparations in preference to live... ...

        Research

        Lessons from the first year of the WAIVE study investigating the protective effect of influenza vaccine

        Influenza is major cause of paediatric hospitalisation. Influenza vaccine was offered to all children aged 6-59 months resident in Western Australia in 2008 ...

        Research

        Comparison of a rapid antigen test with nucleic acid testing during cocirculation of pandemic influenza A/H1N1 09 and Seasonal influena A/H3N2

        The rapid diagnosis of influenza is critical in optimizing clinical management. Rapid antigen tests have decreased sensitivity in detecting pandemic influenza. ...

        Research

        Human Papillomavirus vaccination for the prevention of cervical neoplasia: is it appropriate to vaccinate women older than 26?

        Cervical cancer mortality has been reduced in Australia because of effective screening programs, but there are still about 800 new cases... ...

        Research

        The effects of maternal smoking on early mucosal immunity and sensitization at 12 months of age

        In this study, we examined the effects of maternal smoking as a major adverse exposure in early life, on mucosal immune function and allergen sensitization... ...

        Research

        Pandemic clinical case definitions are non-specific

        During the early phases of the 2009 pandemic, subjects with influenza-like illness only had laboratory testing specific for the new A(H1N1)pdm09 virus. ...

        Research

        Australia-wide point prevalence survey of antimicrobial prescribing in neonatal units: How much and how good?

        This is the first Australia-wide point prevalence survey of neonatal antimicrobial prescribing in tertiary children's hospitals. ...

        Research

        Predictors of Disease Severity in Children Hospitalized for Pertussis during an Epidemic

        This study aimed to determine factors associated with severe pertussis in hospitalized children during an epidemic using a novel pertussis severity scoring... ...

        Research

        Natural history of progression of HPV infection to cervical lesion or clearance: Analysis of the control arm of the large, randomised PATRICIA study

        The control arm of PATRICIA (PApillomaTRIal against Cancer In young Adults, NCT00122681) was used to investigate the risk of progression from cervical HPV... ...

        Research

        Clinical Predictors of Influenza in Young Children: The Limitations of “Influenza-Like Illness”

        This study aims to identify clinical predictors of influenza infection in children ≤5 years old from which age-specific ILI definitions are then constructed. ...

        Research

        Neonatal antigen-presenting cells are functionally more quiescent in children born under traditional compared with modern environmental conditions

        One explanation for the high burden of allergic and autoimmune diseases in industrialized countries is inappropriate immune development under modern... ...

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