Macrophages are the major resident immune cells in human airways coordinating responses to infection and injury. In cystic fibrosis, neutrophils are recruited to the airways shortly after birth, and actively exocytose damaging enzymes prior to chronic infection, suggesting a potential defect in macrophage immunomodulatory function. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2022
• June 2022

COVID-19 is complicated by acute lung injury, and death in some individuals. It is caused by SARS-CoV-2 that requires the ACE2 receptor and serine proteases to enter AEC. We determined what factors are associated with ACE2 expression particularly in patients with asthma and COPD. We obtained lower AEC from 145 people from two independent cohorts, aged 2-89 years, Newcastle (n = 115) and Perth (n = 30), Australia. The Newcastle cohort was enriched with people with asthma (n = 37) and COPD (n = 38). Gene expression for ACE2 and other genes potentially associated with SARS-CoV-2 cell entry was assessed by qPCR, and protein expression was confirmed with immunohistochemistry on endobronchial biopsies and cultured AEC. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2021
• January 2021

Long-term survival after lung transplantation is hindered by the development of bronchiolitis obliterans syndrome (BOS). ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2011
• June 2011

Here we review the current knowledge of key molecular pathways that are dysregulated during persistent goblet cell differentiation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• May 2018

The airway epithelium in asthma displays altered repair and incomplete barrier formation. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2013
• December 2013

Our experiments provide proof of principle for the use of PSC-derived respiratory epithelial cells in the study of cell-virus interactions. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2015
• April 2015

HRV-1B infection directly alters human airway epithelial TJ expression leading to increased epithelial permeability potentially via antiviral response of IL-15 ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• October 2016

Genetic factors in airway epithelial cells that are functionally associated with asthma pathogenesis ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• September 2016

In disease settings, vitamin D may be important for maintaining optimal lung epithelial integrity and suppressing inflammation, but less is known of its effects prior to disease onset. ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2017
• August 2017

Human rhinovirus infection delays repair and inhibits apoptotic processes in epithelial cells from non-asthmatic and asthmatic children ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• November 2016

PLA2R1 is increased in the airway epithelium in asthma, and serves as a regulator of airway hyperresponsiveness, airway permeability, antigen sensitization, and airway inflammation ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2016
• December 2016

We aimed to delineate the effects of LPS and AMP on airway inflammation, and potential contribution to airway disease by measuring airway inflammatory responses ...

• 1. Telethon Kids Institute
• Our research
• Reports and Findings
• 2018
• January 2018