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        Bile Acids and Microbiota Interplay in Pancreatic Cancer

        Evidence suggests the involvement of the microbiota, including oral, intra-tumoral and gut, in pancreatic cancer progression and response to therapy. The gut microbiota modulates the bile acid pool and is associated with maintaining host physiology. Studies have shown that the bile acid/gut microbiota axis is dysregulated in pancreatic cancer. ...

        Research

        The effect of CFTR modulators on structural lung disease in cystic fibrosis

        Newly developed quantitative chest computed tomography (CT) outcomes designed specifically to assess structural abnormalities related to cystic fibrosis (CF) lung disease are now available. CFTR modulators potentially can reduce some structural lung abnormalities. We aimed to investigate the effect of CFTR modulators on structural lung disease progression using different quantitative CT analysis methods specific for people with CF (PwCF). ...

        Research

        Treatment with inhaled aerosolised ethanol reduces viral load and potentiates macrophage responses in an established influenza mouse model

        Treatment options for viral lung infections are currently limited. We aimed to explore the safety and efficacy of inhaled ethanol in an influenza-infection mouse model. ...

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        A phase I clinical trial assessing the safety, tolerability, and pharmacokinetics of inhaled ethanol in humans as a potential treatment for respiratory tract infections

        Current treatments for respiratory infections are severely limited. Ethanol's unique properties including antimicrobial, immunomodulatory, and surfactant-like activity make it a promising candidate treatment for respiratory infections if it can be delivered safely to the airway by inhalation. Here, we explore the safety, tolerability, and pharmacokinetics of inhaled ethanol in a phase I clinical trial. ...

        Research

        Autophagy modulates growth and development in the moss Physcomitrium patens

        Physcomitrium patens apical growing protonemal cells have the singularity that they continue to undergo cell divisions as the plant develops. This feature provides a valuable tool to study autophagy in the context of a multicellular apical growing tissue coupled to development. Herein, we showed that the core autophagy machinery is present in the moss P. patens, and characterized the 2D and 3D growth and development of atg5 and atg7 loss-of-function mutants under optimal and nutrient-deprived conditions. ...

        Research

        Lipopolysaccharide-induced interferon response networks at birth are predictive of severe viral lower respiratory infections in the first year of life

        Appropriate innate immune function is essential to limit pathogenesis and severity of severe lower respiratory infections (sLRI) during infancy, a leading cause of hospitalization and risk factor for subsequent asthma in this age group. ...

        Research

        Changing Prevalence of Lower Airway Infections in Young Children with Cystic Fibrosis

        Aspergillus species and P. aeruginosa are commonly present in the lower airways from infancy ...

        Research

        Microbiome and Functional Analysis of a Traditional Food Process: Isolation of a Novel Species (Vibrio hibernica) With Industrial Potential

        Vibrio hibernica is capable of metabolizing a unique carbohydrate profile at low temperatures ...

        Research

        Association between early respiratory viral infections and structural lung disease in infants with cystic fibrosis

        Infants with cystic fibrosis (CF) develop structural lung disease early in life, and viral infections are associated with progressive lung disease. We hypothesized that the presence of respiratory viruses would be associated with structural lung disease on computed tomography (CT) of the chest in infants with CF. ...

        Research

        Use of a primary epithelial cell screening tool to investigate phage therapy in cystic fibrosis

        This study demonstrates the feasibility of utilizing pre-clinical in vitro culture models to screen therapeutic candidates ...

        Research

        Effect of posture on lung ventilation distribution and associations with structure in children with cystic fibrosis

        Background: We assessed the effect of posture on ventilation distribution and the impact on associations with structural lung disease. ...

        Research

        Air trapping in early cystic fibrosis lung disease-Does CT tell the full story?

        Mosaic attenuation on expiratory chest computed tomography (CT) is common in early life cystic fibrosis (CF) and often referred to as "air trapping" ...

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